Procyclidine is an antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms. A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
- Mechanism
- Curator reviewed
The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation.
- Primary indication
- For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.Curator reviewed · 2 structured indications
- Formula / weight
- C19H29NO · 287.4397 g/mol (avg)
- First approval
- Canada, 2001 · United States, 1955
- Also known as
- Tricyclamol
Resolves to
WYDUSKDSKCASEF-UHFFFAOYSA-NSMILESOC(CCN1CCCC1)(C1CCCCC1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Procyclidine, and which of those have an active Phase 3 trial?
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