Spiramycin

DB06145ApprovedInvestigationalWithdrawnSmall moleculeMacrolide Antimicrobial

Spiramycin is a macrolide antimicrobial agent used in the treatment of various bacterial infections. Spiramycin is a primarily bacteriostatic macrolide antimicrobial agent with activity against Gram-positive cocci and rods, Gram-negative cocci and also Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii and Cryptosporidium.

Mechanism: The mechanism of action of macrolides has been a matter of controversy for some time. Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1: 1 stoichiometry. This antibiotic is a potent inhibitor of the binding to the ribosome of both donor and acceptor substrates. The primary mechanism of action is done by stimulation of dissociation of peptidyl-tRNA from ribosomes during translocation.I
Curator reviewed
Primary indication: Macrolide antibiotic for treatment of various infections.Curator reviewed · 1 structured indication
Formula / weight: C₄₃H₇₄N₂O₁₄ · 843.065 g/mol (avg)
First approval: Canada, 2004
Also known as: Demycarosylturimycin H · Foromacidin A · Foromacidine A · Spiramycin 1 · Spiramycin A

Resolves to

Compound

UNII033ECH6IFGCAS24916-50-5ChEMBLCHEMBL453514ChEBI85260PubChem6440717

Clinical / RWD

RxNorm9991ATCJ01FA02ATCJ01RA04

Structure

InChIKeyACTOXUHEUCPTEW-CEUOBAOPSA-NSMILES

[H][C@@]1(CC[C@@H]([C@@H](C)O1)N(C)C)O[C@H]1\C=C\C=C\C[C@@H](C)OC(=O)C[C@@H](O)[C@H](OC)[C@@H](O[C@]2([H])O[C@H](C)[C@@H](O[C@@]3([H])C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@H]1C

Targets

Q9A1X4rplC

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

84Drug interactionsStructured to mechanism, not free text

5Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

2ContraindicationsEach with its own population and attribute set

57Marketed productsAcross 7 countries and 29 labellers

2ATC codesIncluding every combination product, plus 17 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Spiramycin, and which of those have an active Phase 3 trial?

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