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Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalA vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. … The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL
Synonyms: β,β'-dichlorodiethyl-N-methylamine, N-methyl-bis(2-chloroethyl)amineCategories: Compounds used in a research, industrial, or household settingMirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigationalMirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. … Mirabegron has a comparatively favorable adverse effect profile as compared to other available treatment options, and its complementary mechanism to the antimuscarinics that came before it allows for its
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: MYRBETRIC® 50 MG TABLETAS DE LIBERACION PROLONGADA, MYRBETRIC® 25 MG TABLETAS DE LIBERACION PROLONGADAAspergillus repens
go.drugbank.com/drugs/DB10449ApprovedAspergillus repens is a fungus which can provoke allergic reactions. Aspergillus repens extract is used in allergenic testing.
Mixtures: Number Ten Mold Mixture, Number Ten Mold MixtureDalfopristin
go.drugbank.com/drugs/DB01764ApprovedDalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. … Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsZongertinib
go.drugbank.com/drugs/DB18762ApprovedInvestigational[L53873,A274363] On August 8, 2025, the US FDA granted accelerated approval to zongertinib for the treatment of advanced forms of non-small cell lung cancer (NSCLC) with HER2 tyrosine kinase domain … Zongertinib is a selective, irreversible tyrosine kinase inhibitor that targets human epidermal growth factor receptor 2 (HER2).
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingGamolenic acid
go.drugbank.com/drugs/DB13854ApprovedWithdrawnGamolenic acid is produced minimally in the body as the delta 6-desaturase metabolite of [DB00132]. It is converted to [DB00154], a biosynthetic precursor of monoenoic prostaglandins such as PGE1. … Gamolenic acid may be found in over-the-counter dietary supplements. Gamolenic acid is also found in some fungal sources and also present naturally in the form of triglycerides [F27].
Synonyms: 18:3 (n-6), (Z,Z,Z)-6,9,12-octadecatrienoic acidMixtures: PRIM E CAPSULE, Evening Primrose Oil Cap 500mg W Vit ELacidipine
go.drugbank.com/drugs/DB09236ApprovedLacidipine is a highly lipophilic molecule that interacts with the biological membranes. … It is available as once-daily oral tablets containing 2 or 4 mg of the active compound commonly marketed as Lacipil or Motens. It is not currently FDA-approved.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: LACIPIL TABLET 4 mg, LACIPIL 4 MG FILM KAPLI TABLET, 14 ADETNadofaragene firadenovec
go.drugbank.com/drugs/DB17381ApprovedInvestigationalIt is the first gene therapy approved by the FDA for the treatment of bladder cancer.[L44381,L44431] BCG-unresponsive NMIBC has a high recurrence and is notably difficult to treat. … Compared to [pembrolizumab], a smaller proportion of patients experienced grade 3-4 adverse events (4% vs 12.7%).[A255111]
Synonyms: Replication-deficient adenovirus type 5 (ad5) vector encoding the human interferon alpha 2 (ifna2, interferon alpha-2b) gene under the control of the cytomegalovirus (cmv) immediate-early enhancer/promoter, TR-002Etorphine
go.drugbank.com/drugs/DB01497ExperimentalIllicitVet approvedEtorphine is only available to the patients under an official prescription. In the US, Etorphine is listed as a Schedule I drug, although Etorphine hydrochloride is classified as Schedule II. … In certain countries, etorphine is classified as a Schedule 1 drug and hence, in these countries, it can be used legally only by health professionals and for research purposes.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds with 4 or More RingsRecombinant stabilized RSV B prefusion F antigen
go.drugbank.com/drugs/DB18714ApprovedInvestigational[L49560] It is the first RSV vaccine approved for use in pregnant patients to prevent RSV in infants.[L49555] … The vaccine comprises two antigens - the other being [recombinant stabilized RSV A prefusion F antigen] - which have been expressed in Chinese hamster ovary cell lines and then purified and lyophilized
Synonyms: Recombinant stabilized RSV B prefusion F antigen, RSV subgroup B stabilized prefusion F protein