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Displaying results 3171 - 3180 of 10000 in total
  1. Drug

    INCB13739

    go.drugbank.com/drugs/DB05064
    Investigational

    INCB13739 is developed as a new treatment for type 2 diabetes.

  2. Drug

    Velusetrag

    go.drugbank.com/drugs/DB12702
    Investigational

    Velusetrag was discovered by Theravance through the application of its multivalent drug design in a research program dedicated to finding new treatments for GI motility disorders. … It is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is being developed by Theravance.

  3. Drug

    Prifinium

    go.drugbank.com/drugs/DB13254
    Experimental

    It may be useful for the treatment of irritable bowel syndrome [A175027].

    Categories: Drugs for Functional Gastrointestinal Disorders
  4. Drug

    Dimetindene

    go.drugbank.com/drugs/DB08801
    ApprovedInvestigational

    Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.

    Categories: Antihistamines for Topical Use, Antihistamines for Systemic Use
  5. Drug

    Pexiganan

    go.drugbank.com/drugs/DB16293
    Investigational

    Pexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).

    Categories: Pore Forming Cytotoxic Proteins
  6. Drug

    Talazoparib

    go.drugbank.com/drugs/DB11760
    ApprovedInvestigational

    Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index
  7. Drug

    Ouabain

    go.drugbank.com/drugs/DB01092
    Approved

    It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. … A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: Ouabagenin-L-rhamnosid, Ouabagenin L-Rhamnoside
  8. Drug

    MK-0354

    go.drugbank.com/drugs/DB05939
    Investigational

    It targets G protein-coupled receptor, or GPCR, that have the potential to regulate plasma lipid profiles, including HDL, or the good cholesterol, similar to the therapeutic action of niacin. … MK-0354, is an orally administered drug candidate under development by Merck for the treatment of atherosclerosis and related disorders.

  9. Drug

    Oxaliplatin

    go.drugbank.com/drugs/DB00526
    ApprovedInvestigational

    [A797] Although oxaliplatin has been investigated as a monotherapy, it is typically administered in combination with fluorouracil and leucovorin, known as the FOLFOX regimen, for the treatment of colorectal … Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin.

    Categories: OCT2 Substrates with a Narrow Therapeutic IndexSynonyms: L-OHP
  10. Drug

    Coumaphos

    go.drugbank.com/drugs/DB11390
    ExperimentalVet approved

    This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a _dip_ or _wash_. … Coumaphos is widely used for both farm and domestic animals to control ticks, mites, flies and fleas.

    Categories: Compounds used in a research, industrial, or household setting