Dimetindene

DB08801ApprovedInvestigationalSmall molecule

Dimetindene is a 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.

Chemical structure of Dimetindene
Mechanism
Curator reviewed
Primary indication
Indicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except pruritus due to cholestasis; insect...Curator reviewed · 12 structured indications
Formula / weight
C20H24N2 · 292.418 g/mol (avg)
Also known as
Dimethindene

Resolves to

Compound
UNII661FH77Z3PCAS5636-83-9ChEMBLCHEMBL22108ChEBI135222PubChem21855KEGGD07853
Clinical / RWD
RxNorm3449ATCD04AA13ATCR06AB03PharmGKBPA165958420
Structure
InChIKeyMVMQESMQSYOVGV-UHFFFAOYSA-NSMILESCC(C1=C(CCN(C)C)CC2=CC=CC=C12)C1=CC=CC=N1
Targets
P35367HRH1P08172CHRM2

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
526Drug interactionsStructured to mechanism, not free text
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5Clinical trialsPhase, status and sponsor resolved per trial
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12Structured indicationsCondition, population, route and combination as fields, not prose
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15ContraindicationsEach with its own population and attribute set
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54Marketed productsAcross 6 countries and 14 labellers
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2ATC codesIncluding every combination product, plus 16 drug categories
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20+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Dimetindene, and which of those have an active Phase 3 trial?

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