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IL15-NK Cell
go.drugbank.com/drugs/DB15725InvestigationalIn particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to. … Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity.
Synonyms: IL15-NK CellDuvelisib
go.drugbank.com/drugs/DB11952ApprovedInvestigationalcan produce a broad adaptative and innate immune cell inhibitory activity. … All the work around duvelisib showed that this agent is a potent inhibitor of both forms.[A39025] Duvelisib was developed by Verastem, Inc and FDA approved on September 24, 2018.[L4585]
Categories: Antineoplastic and Immunomodulating AgentsHuman botulinum neurotoxin A/B immune globulin
go.drugbank.com/drugs/DB14115Approved[L39834] It is produced and distributed by the Calfornia Department of Public Health's Infant Botulism Treatment and Prevention Program[L39829] and comprises IgG antibodies derived from pooled adult plasma … [L39819,L39824] BabyBIG (human-derived botulism immunoglobulin) was approved for use by the FDA in 2003[L39814] and has since been used to treat more than 2100 cases of infant botulism.
Synonyms: Botulism immune globulin IV human, Botulism immune globulin intravenous (human) (BIG-IV)Deucravacitinib
go.drugbank.com/drugs/DB16650ApprovedInvestigational[L43150] It was later approved by Health Canada in November 2022 [L44216] and by the European Medicines Agency in March 2023.[L45788] … [A246943] Deucravacitinib was first approved by the FDA in September 2022 to treat moderate-to-severe plaque psoriasis.
Categories: Antineoplastic and Immunomodulating AgentsAlmitrine
go.drugbank.com/drugs/DB01430ApprovedAlmitrine is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. … It is used in the treatment of chronic obstructive pulmonary disease.
Categories: Compounds used in a research, industrial, or household settingBacillus calmette-guerin substrain russian BCG-I live antigen
go.drugbank.com/drugs/DB16648ApprovedInvestigationalthought to work by stimulating a local immune and inflammatory response in the bladder. … [L32734] It is to be marketed by Verity Pharmaceuticals, under the trade name VERITY-BCG, and manufactured by the Serum Institute of India.
Synonyms: Bacillus Calmette-Guérin (BCG) - strain russian BCG-I, Bacillus calmette-guerin substrain russian BCG-I live antigenCalaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalAsparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) [A40270]. … Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation.
Categories: Compounds used in a research, industrial, or household setting, Enzymes and CoenzymesRelugolix
go.drugbank.com/drugs/DB11853ApprovedInvestigationalIt was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids,[A225816] and more recently by the United States' FDA in 2020, under the brand name … [A225926] In May 2021, the FDA approved the combination product made up of relugolix, [estradiol], and [norethindrone] under the market name Myfembree for the first once-daily treatment for the management
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsAmylmetacresol
go.drugbank.com/drugs/DB13908ApprovedPharyngitis is normally caused by viruses and proves benign and self-limiting. … Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections [L2570], [L2571].
Synonyms: 6-n-amyl-m-cresol, 6-n-pentyl-m-cresolMixtures: STREPSILS HONEY AND LEMON, STREPSILS SORE THROAT AND BLOCKED NOSE LOZENGEBAX 335
go.drugbank.com/drugs/DB17845InvestigationalBAX 335 is an adeno-associated virus vector 8 (AAV8)–based FIX gene therapy being investigated for the treatment of hemophilia B.[A259791]
Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsSynonyms: An Adeno-Associated Virus Serotype 8 (AAV8) Vector Expressing FIX Padua (AAV8.ss-3xCRM8-TTRFIX_R338Lopt)