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Obinutuzumab
go.drugbank.com/drugs/DB08935ApprovedInvestigational[L54521] Like other drugs in its class, obinutuzumab targets the CD20 antigen expressed on the surface of pre-B and mature B lymphocytes, mediating B-cell lysis. … [A274641] As a result, obinutuzumab induces greater antibody-dependent cellular cytotoxicity (ADCC) and a higher degree of direct cell death compared to rituximab.
Categories: CD20 (Clusters of Differentiation 20) inhibitors, Amino Acids, Peptides, and ProteinsProducts: GAZYVA 1000 MG IV İNFÜZYONLUK KONSANTRE ÇÖZELTİ, 1 ADET, GAZYVA ® CONCENTRADO PARA SOLUCIÓN PARA INFUSIÓN 1000 MG / VIAL 40 MLButenafine
go.drugbank.com/drugs/DB01091ApprovedButenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols.
Synonyms: N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine, (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amineProducts: BUTAFLY % 1 LOSYON ,10 ML, BUTEFIN %1 KREM, 15 GAbrocitinib
go.drugbank.com/drugs/DB14973ApprovedInvestigationalAbrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). … [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases,
Categories: Heterocyclic Compounds, 1-Ring, Janus Kinase 1, antagonists & inhibitorsProducts: CIBINQO® 50 MG, CİBİNQO 50 MG FİLM KAPLI TABLET, 28 ADETNilotinib
go.drugbank.com/drugs/DB04868ApprovedInvestigationalA Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to treatment with imatinib (Gleevec … Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML).
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsProducts: TASIGNA® 150 MG CAPSULAS, TASIGNA 150 MG KAPSUL, 28 ADETPrucalopride
go.drugbank.com/drugs/DB06480ApprovedInvestigational[A40254] Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009,[A40250] in Canada on December 7, 2011 and by the FDA on December 17, 2018.[L4880] … Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties.
Categories: Serotonin 5-HT4 Receptor Agonists, Alimentary Tract and MetabolismProducts: Resolor Film-coated Tablet 1 mg, RESOLOR ® TABLETAS RECUBIERTAS DE 1 MGAlectinib
go.drugbank.com/drugs/DB11363ApprovedInvestigationalInhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting in reduced tumour cell viability. … Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsSynonyms: 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrileDisopyramide
go.drugbank.com/drugs/DB00280ApprovedInvestigationalA class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar … It also possesses some anticholinergic and local anesthetic properties.
Categories: Heterocyclic Compounds, 1-Ring, Antiarrhythmics, Class IProducts: NORPACE 100 MG KAPSÜL, 50 ADET, NORPACE 100 MG KAPSÜL, 25 ADETDimetindene
go.drugbank.com/drugs/DB08801ApprovedInvestigationalDimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.
Categories: Heterocyclic Compounds, 1-RingProducts: Dimestil 1 mg/g Gel, Fenistil 1 mg - DrageesSelenium
go.drugbank.com/drugs/DB11135ApprovedInvestigationalVet approvedSelenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen
Mixtures: Vitamin E 400 I.U. & Selenium 50 Mcg Capsules, PreQue 10Categories: Compounds used in a research, industrial, or household setting, Diet, Food, and NutritionBismuth subsalicylate
go.drugbank.com/drugs/DB01294ApprovedVet approvedEach molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. … [A230733] Bismuth subsalicylate has been around for over 100 years: it was originally developed in 1901 for hygienic use and sanitation for cholera infection.
Mixtures: Pepto-Bismol and Pepto-Bismol To Go, Pepto-Bismol and Pepto-Bismol To GoCategories: Antacids and Adsorbents