Selenium

Identification

Name
Selenium
Accession Number
DB11135
Description

Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species Label

Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Structure
Thumb
Weight
Average: 78.96
Monoisotopic: 79.916521828
Chemical Formula
Se
Synonyms
  • Selen
  • Selenio
  • Sélénium
  • Selenium elemental
  • Selenium metallicum
  • Selenium, elemental
External IDs
  • 231-957-4
  • C.I. 77805
  • CI 77805

Pharmacology

Indication

For the supplementation of total parenteral nutrition to prevent hyposelenemia Label.

Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Selenium is incorporated into many different selenoproteins which serve various functions throughout the body 1.

Mechanism of action

Selenium is first metabolized to selenophosphate and selenocysteine. Selenium incorporation is genetically encoded through the RNA sequence UGA 1. This sequence is recognized by RNA ste loop structures called selenocysteine inserting sequences (SECIS). These structures require the binding of SECIS binding proteins (SBP-2) to recognize selenocystiene. The specialized tRNA is first bound to a serine residue which is then enzymatically processed to a selylcysteyl-tRNA by selenocystiene sythase using selenophosphate as a selenium donor. Other unidentified proteins are required as part of the binding of this tRNA to the ribosome. Selenoproteins appear to be necessary for life as mice with the specialized tRNA gene knocked out exhibited early embryonic lethality 2.

The most important selenoproteins seem to be the glutathione peroxidases and thioredoxin reductases which are part of the body's defenses againts reactive oxygen species (ROS) 1. The importance of selenium in these anti-oxidant proteins has been implicated in the reduction of atherosclerosis by preventing the oxidation of low density lipoprotein 7 3. Selenium supplementation is also being investigated in the prevention of cancer and has been suggested to be beneficial to immune function 7 4 5.

Absorption

Oral bioavailability of 90% when given as L-selenomethionine 8. Tmax of 9.17h.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Selenium supplements are typically available in the form of sodium selenite which is metabolized to selenide through either glutathione conjugation and subsequent reduction by glutathione reductase enzymes or reduction by thioredoxin reductases 1. Selenide is further metabolized to selenocystein by cysteine synthases and to selenophosphate by selenophosphate synthases. Selenide is also metabolized progressively to methyl-selenol, dimethyl selenide, then trimethylselenonium. Selenocysteine is degraded to methyl-selenol, pyruvate and ammonia by cysteine beta lyase. Selenocystein reacts with oxygen to form selenocysteine selenoxide which spontaneously degrades to methylselenic acid, pyruvate and ammonia. Methylselenic acid can be converted to methylselenol via conjugation with thiol groups on proteins like glutathione.

Route of elimination

Mainly excreted in urine as 1beta-methylseleno-N-acetyl-d-galactosamine and trimethylselenonium 6. The amount excreted as 1beta-methylseleno-N-acetyl-d-galactosamine plateaus at doses around 2microg after which the amount excreted as trimethylselenonium increases. Some selenium is also excreted in feces when given orally 8.

Half-life

Half life was observed to increase with chronic dosing time 8. For day 1-2 half life was 1.7 days. For day 2-3 half life was 3 days. For day 3-14 half life was 11.1 days.

Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity

Oral LD50 of 6700mg/kg in rats MSDS. Selenium exposure is teratogenic and can result in fetal death as tested in mice. Chronic toxicity is characterized by hair loss, white horizontal streaking on fingernails, paronchyia, fatigue, irritability, hyperreflexia, nausea, vomiting, garlic odor on breath, and metallic taste Label. Serum selenium correlates weakly with symtoms. Blood chemistry as well as liver and kidney function are normally unnaffected. Acute toxicity presents as stupor, respiratory depression, and hypotension. ST elevations and t-wave changes characteristic of myocardial infarction may be observed.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Selenium which could result in a higher serum level.
AcarboseAcarbose may decrease the excretion rate of Selenium which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Selenium which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Selenium which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Selenium which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Selenium which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Selenium which could result in a higher serum level.
AclidiniumAclidinium may decrease the excretion rate of Selenium which could result in a higher serum level.
AcrivastineAcrivastine may decrease the excretion rate of Selenium which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Selenium which could result in a higher serum level.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
No interactions found.

Products

International/Other Brands
B-Traxim Se / Selsaf 2000
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Selenious AcidInjection, solution60 ug/1mLIntravenousAMERICAN REGENT, INC.2019-07-01Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Bio Selenium Tab 50mcgTabletOralSantÉ Naturelle (Ag) LtÉe1988-12-312001-07-06Canada flag
Davinci Selenium Tab 50mcgTabletOralFoodscience Laboratories, Division Of Foodscience Corporation1988-12-311997-05-08Canada flag
Gnc Selenium 50mcg TabletTabletOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada flag
SeleniumCapsule200 mcgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.2000-01-212002-07-29Canada flag
Selenium 100 - CapletTabletOralHealth Wise Nutrition Inc.1995-12-312002-07-18Canada flag
Selenium 100mcgTabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada flag
Selenium 200 McgTabletOralHolista Health (Canada) Inc.2003-02-052008-07-17Canada flag
Selenium 200 McgTabletOralPreferred Nutrition Inc.2004-05-122005-08-04Canada flag
Selenium 200 Mcg TabletsTabletOralPharmetics (2011) Inc.1999-08-082009-07-30Canada flag
Selenium 200mcgTabletOralPharmavite1997-08-252006-07-05Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
24 Multivitamins + MineralsSelenium (20 mcg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-04-302002-07-31Canada flag
50 Plus Multiple Vitamins & MineralsSelenium (25 mcg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)TabletOralGfr Pharma Ltd.2002-10-202004-06-15Canada flag
A.R.T.H. Away FormulaSelenium (1.54 mcg) + Calcium (24 mg) + Cholecalciferol (45 unit) + Copper (0.232 mg) + Folic acid (0.025 mg) + Manganese (0.58 mg) + Pyridoxine hydrochloride (0.5 mg) + Zinc (0.63 mg)CapsuleOralAbundance Naturally Ltd1999-02-012006-06-16Canada flag
A/o-26 - CapletSelenium (100 mcg) + Beta carotene (7500 unit) + Calcium (75 mg) + Calcium ascorbate (250 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Manganese (2.5 mg) + Racemethionine (50 mg) + Zinc (7.5 mg)TabletOralEnviro Tech International Canada1996-12-191999-07-26Canada flag
Aces Formula/formule A A SSelenium (25 mcg) + Ascorbic acid (250 mg) + Beta carotene (3333 unit) + Vitamin E (400 unit)CapsuleOralQuantofill Inc.Not applicableNot applicableCanada flag
Aces TabSelenium (100 mcg) + Calcium ascorbate (350 mg) + Cholecalciferol (200 unit) + Chromium (25 mcg) + Vitamin A (5000 unit) + Vitamin E (200 unit) + Zinc (25 mg)TabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada flag
Adrien Gagnon Formule A-C-E + SeleniumSelenium (50 mcg) + Beta carotene (10000 unit) + Calcium ascorbate (500 mg) + Vitamin E (200 unit)CapsuleOralSantÉ Naturelle (Ag) LtÉe2002-02-222007-08-03Canada flag
Adult Formula 50+Selenium (10 mcg) + Ascorbic acid (120 mg) + Beta carotene (3000 unit) + Biotin (30 mcg) + Calcium (220 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Iodine (0.15 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Molybdenum (10 mcg) + Nicotinamide (20 mg) + Calcium pantothenate (20 mg) + Potassium (37.5 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (3.4 mg) + Thiamine hydrochloride (4.5 mg) + Vitamin A palmitate (3000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralWn Pharmaceuticals Ltd.2002-04-252009-09-28Canada flag
Advanced B & T FormulaSelenium (33.33 mcg) + Ascorbic acid (33.3 mg) + Calcium (200 mg) + Chromium (33.33 mcg) + Copper (0.5 mg) + Cyanocobalamin (6.67 mcg) + Folic acid (0.133 mg) + Iron (1.67 mg) + Magnesium (83.3 mg) + Manganese (3.33 mg) + Nicotinamide (6.67 mg) + Calcium pantothenate (5 mg) + Phosphorus (100 mg) + Potassium (16.67 mg) + Pyridoxine hydrochloride (6.67 mg) + Riboflavin (2.67 mg) + Silicon (0.333 mg) + Sodium molybdate (16.67 mcg) + Thiamine (2.67 mg) + Vanadium (8.33 mg) + Vitamin D (66.67 unit) + Zinc (5 mg)CapsuleOralNutraceutical CorporationNot applicableNot applicableCanada flag
Am CapsSelenium (50 mcg) + Beta carotene (2500 unit) + Biotin (150 mcg) + Calcium ascorbate (30 mg) + Cholecalciferol (200 unit) + Cyanocobalamin (5 mcg) + Folic acid (0.20 mg) + Nicotinamide (10 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (0.85 mg) + Thiamine (0.75 mg) + Vitamin E (15 unit)CapsuleOralNew Vision Nutritionals CompanyNot applicableNot applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Folet DHASelenium (65 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2700 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (18 [iU]/1) + Doconexent (350 mg/1) + Docusate sodium (50 mg/1) + Ferrous bisglycinate (38 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (40 mg/1) + Riboflavin (3.4 mg/1) + Thiamine hydrochloride (3 mg/1) + Zinc glycinate (10 mg/1)OralPronova Corporation2014-08-282017-03-15US flag
Nata KompleteSelenium (50 ug/1) + Ascorbic acid (120 mg/1) + Biotin (30 ug/1) + Calcium (100 mg/1) + Cholecalciferol (400 [iU]/1) + Choline bitartrate (55 mg/1) + Copper (2 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (25 mg/1) + Magnesium (50 mg/1) + Niacin (20 mg/1) + Pantothenic acid (8 mg/1) + Pyridoxine (30 mg/1) + Riboflavin (3.5 mg/1) + Thiamine chloride (3 mg/1) + Vitamin A (2700 [iU]/1) + Vitamin E (20 [iU]/1) + Zinc (15 mg/1)TabletOralWh Nutritionals, Llc2011-06-252014-05-31US flag
Prefera OB plus DHASelenium (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron Dextran (22 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralAlaven Pharmaceutical LLC2009-04-012019-01-01US flag
PreferaOBSelenium (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron Dextran (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 ug/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralAlaven Pharmaceutical LLC2010-09-272019-01-01US flag
PreferaOB plus DHASelenium (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron Dextran (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 ug/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralAlaven Pharmaceutical LLC2010-11-152019-01-01US flag
PreQue 10Selenium (7.5 ug/1) + Ascorbic acid (30 mg/1) + Cholecalciferol (120 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (1 ug/1) + Doconexent (50 mg/1) + Docusate sodium (25 mg/1) + Folic acid (0.5 mg/1) + Iron (15 mg/1) + Lycopene (5 mg/1) + Magnesium oxide (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1 mg/1) + Ubidecarenone (50 mg/1) + Vitamin A (1250 [iU]/1) + Vitamin E (15 [iU]/1) + Zinc oxide (12.5 mg/1)TabletOralActavis Pharma, Inc.2011-11-012017-10-31US flag
PreQue 10Selenium (7.5 ug/1) + Ascorbic acid (30 mg/1) + Cholecalciferol (120 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (1 ug/1) + Doconexent (50 mg/1) + Docusate sodium (25 mg/1) + Folic acid (0.5 mg/1) + Iron (15 mg/1) + Lycopene (5 mg/1) + Magnesium oxide (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1 mg/1) + Ubidecarenone (50 mg/1) + Vitamin A (1250 [iU]/1) + Zinc oxide (12.5 mg/1) + alpha-Tocopherol succinate (15 [iU]/1)TabletOralPhysicians Total Care, Inc.2011-11-012013-02-11US flag
Strovite Forte CapletSelenium (50 ug/1) + Ascorbic acid (500 mg/1) + Biotin (0.15 mg/1) + Chromium (50 ug/1) + Copper (3 mg/1) + Cyanocobalamin (50 ug/1) + Folic acid (1 mg/1) + Iron (10 mg/1) + Magnesium (50 mg/1) + Molybdenum (20 ug/1) + Niacin (100 mg/1) + Pantothenic acid (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Thiamine mononitrate (20 mg/1) + Vitamin A (4000 [iU]/1) + Vitamin D (400 [iU]/1) + Vitamin E (60 [iU]/1) + Zinc (15 mg/1)Tablet, coatedOralEverett Laboratories, Inc.1996-10-01Not applicableUS flag
Strovite One CapletsSelenium (100 ug/1) + Ascorbic acid (300 mg/1) + Biotin (100 ug/1) + Cholecalciferol (1000 [iU]/1) + Chromium (50 ug/1) + Cupric sulfate pentahydrate (1.5 mg/1) + Cyanocobalamin (50 ug/1) + Folic acid (1 mg/1) + Lipoic acid (15 mg/1) + Lutein (5 mg/1) + Magnesium oxide (50 mg/1) + Manganese (1.5 mg/1) + Nicotinamide (25 mg/1) + Calcium pantothenate (7.5 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine chloride (20 mg/1) + Vitamin A (3000 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol succinate (100 [iU]/1)TabletOralExeltis Usa, Inc.2001-05-04Not applicableUS flag
Vitaphil 90 DHASelenium (50 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2600 [iU]/1) + Biotin (30 ug/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (420 [iU]/1) + Choline bitartrate (60 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Doconexent (200 mg/1) + Folic acid (1 mg/1) + Iron (26 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (8 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin (3.5 mg/1) + Thiamine hydrochloride (3 mg/1) + Vitamin E (20 [iU]/1) + Zinc oxide (15 mg/1)KitOralRiver's Edge Pharmaceuticals, LLC2008-11-142010-10-30US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous other non-metal compounds
Sub Class
Not Available
Direct Parent
Homogeneous other non-metal compounds
Alternative Parents
Not Available
Substituents
Homogeneous other non metal
Molecular Framework
Not Available
External Descriptors
nonmetal atom, chalcogen (CHEBI:27568)

Chemical Identifiers

UNII
H6241UJ22B
CAS number
7782-49-2
InChI Key
BUGBHKTXTAQXES-UHFFFAOYSA-N
InChI
InChI=1S/Se
IUPAC Name
selanylidene
SMILES
[Se]

References

General References
  1. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [PubMed:10469608]
  2. Brenneisen P, Steinbrenner H, Sies H: Selenium, oxidative stress, and health aspects. Mol Aspects Med. 2005 Aug-Oct;26(4-5):256-67. [PubMed:16105679]
  3. Zhang H, Luo Y, Zhang W, He Y, Dai S, Zhang R, Huang Y, Bernatchez P, Giordano FJ, Shadel G, Sessa WC, Min W: Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol. 2007 Mar;170(3):1108-20. [PubMed:17322393]
  4. Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, Arthur JR, Jackson MJ: An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am J Clin Nutr. 2004 Jul;80(1):154-62. [PubMed:15213043]
  5. Lippman SM, Goodman PJ, Klein EA, Parnes HL, Thompson IM Jr, Kristal AR, Santella RM, Probstfield JL, Moinpour CM, Albanes D, Taylor PR, Minasian LM, Hoque A, Thomas SM, Crowley JJ, Gaziano JM, Stanford JL, Cook ED, Fleshner NE, Lieber MM, Walther PJ, Khuri FR, Karp DD, Schwartz GG, Ford LG, Coltman CA Jr: Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst. 2005 Jan 19;97(2):94-102. [PubMed:15657339]
  6. Suzuki KT, Kurasaki K, Okazaki N, Ogra Y: Selenosugar and trimethylselenonium among urinary Se metabolites: dose- and age-related changes. Toxicol Appl Pharmacol. 2005 Aug 1;206(1):1-8. Epub 2004 Dec 8. [PubMed:15963339]
  7. Tinggi U: Selenium: its role as antioxidant in human health. Environ Health Prev Med. 2008 Mar;13(2):102-8. doi: 10.1007/s12199-007-0019-4. Epub 2008 Feb 28. [PubMed:19568888]
  8. Bugel S, Larsen EH, Sloth JJ, Flytlie K, Overvad K, Steenberg LC, Moesgaard S: Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium. Food Nutr Res. 2008;52. doi: 10.3402/fnr.v52i0.1642. Epub 2008 Feb 12. [PubMed:19109661]
KEGG Compound
C01529
PubChem Compound
6326970
PubChem Substance
347827913
ChemSpider
4885617
RxNav
9641
ChEBI
27568
Wikipedia
Selenium
AHFS Codes
  • 88:29.00* — Minerals
FDA label
Download (150 KB)
MSDS
Download (110 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentPeripartum Cardiomyopathy1
4CompletedPreventionCardiovascular Heart Disease / Chronic Obstructive Pulmonary Disease (COPD)1
4CompletedPreventionKidney Stones1
4CompletedTreatmentStatin Therapy1
4RecruitingTreatmentAntioxidants / Men Infertility / Semen Quality1
4RecruitingTreatmentHyperuricemia1
3Active Not RecruitingPreventionLung Cancers1
3CompletedPreventionCataracts / Macular Degeneration1
3CompletedPreventionColorectal Cancers / Precancerous Conditions1
3CompletedPreventionPrecancerous/Nonmalignant Condition / Prostate Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral200 mg
Tablet, film coatedOral5000 IU
Tablet, extended releaseOral
Tablet, delayed releaseOral
Tablet
PowderOral
Capsule, gelatin coatedOral
LiquidOral
TabletOral8.3 mg
TabletOral
CapsuleOral
Injection, solutionIntravenous60 ug/1mL
CapsuleOral200 mcg
TabletOral200 mcg
CapsuleOral
Tablet, extended releaseOral
TabletOral
Tablet, coatedOral
Capsule, liquid filledOral562.85 mg
Capsule, coatedOral
Capsule, liquid filledOral200 mg
KitOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)217MSDS
boiling point (°C)684.9MSDS
water solubilityInsolubleMSDS
logP5MSDS
Predicted Properties
PropertyValueSource
logP0.15ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.11 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Transferase activity
Specific Function
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
Gene Name
SCLY
Uniprot ID
Q96I15
Uniprot Name
Selenocysteine lyase
Molecular Weight
48148.45 Da
References
  1. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [PubMed:10469608]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Nadp binding
Specific Function
Maintains high levels of reduced glutathione in the cytosol.
Gene Name
GSR
Uniprot ID
P00390
Uniprot Name
Glutathione reductase, mitochondrial
Molecular Weight
56256.565 Da
References
  1. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [PubMed:10469608]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Thioredoxin-disulfide reductase activity
Specific Function
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enha...
Gene Name
TXNRD1
Uniprot ID
Q16881
Uniprot Name
Thioredoxin reductase 1, cytoplasmic
Molecular Weight
70905.58 Da
References
  1. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [PubMed:10469608]

Drug created on December 03, 2015 09:51 / Updated on September 27, 2020 08:17

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