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CIGB 300
go.drugbank.com/drugs/DB16464InvestigationalCIGB-300, is under investigation in clinical trials for its potential to treat various conditions, including NCT01639638 (recurrent and nonrecurrent condyloma) and NCT01639625 (squamous cell carcinoma
Categories: Experimental Unapproved Treatments for COVID-19Ethylenediamine
go.drugbank.com/drugs/DB14189ApprovedEthylenediamine is an organic compound that is used as a building block for the production of many other chemical products.
Axatilimab
go.drugbank.com/drugs/DB16388ApprovedInvestigational[L51194] It is targeted against macrophage colony-stimulating factor 1 receptor (CSF-1R), causing a reduction in circulating levels of monocytes and macrophages responsible for the symptoms associated … [A264309] Axatilimab was approved by the FDA in August 2024 for the third-line treatment of cGVHD.
Categories: Colony Stimulating Factor-1 Receptor BlockerPrifinium
go.drugbank.com/drugs/DB13254ExperimentalIt may be useful for the treatment of irritable bowel syndrome [A175027].
Categories: Drugs for Functional Gastrointestinal DisordersAmylocaine
go.drugbank.com/drugs/DB09088ApprovedWithdrawnAlthough amylocaine could be administered topically or injected, it was most widely used for spinal anesthesia [L1882]. … Despite the introduction of using cocaine injections for regional anesthesia in 1884, non-addictive substitutes were sought after immediately [L1882].
Rocaglamide
go.drugbank.com/drugs/DB15495Experimental[A186796] Reports of _Aglaia_ anti-tumor activity date back as far as 1973, and rocaglamide-A was first isolated in 1982 from the species _A. elliptifolia_. … [didesmethylrocaglamide]) are currently being studied for use as chemotherapeutic agents in the treatment of various leukemias, lymphomas, and carcinomas, as well as adjuvant therapy in the treatment of
Nalmefene
go.drugbank.com/drugs/DB06230ApprovedInvestigationalWithdrawnIt is used for complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids. … [L1024] Nalmefene was approved in the United States in 1995 as an antidote for opioid overdose.[A245839] Nalmefene injection is used to manage known or suspected opioid overdose.
Rindopepimut
go.drugbank.com/drugs/DB05374InvestigationalThe US FDA granted it Breakthrough Therapy Designation for glioblastoma in Feb 2015.