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Benzocaine
go.drugbank.com/drugs/DB01086ApprovedInvestigationalBenzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Synonyms: p-Carbethoxyaniline, Ethyl p-aminobenzoateMixtures: EMEDUR 100 MG/20 MG SUPOZİTUAR, 5 ADET, ANZİBEL 5 MG/4 MG/3 MG EKİNEZYALI PASTİL, 20 ADETDigitoxin
go.drugbank.com/drugs/DB01396ApprovedWithdrawnA cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: Digimerck 0,1 mg/ml - Injektionslösung, Digimerck 0,07 mg - TablettenBinimetinib
go.drugbank.com/drugs/DB11967ApprovedInvestigationalBinimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib]. … [A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array BioPharma Inc.) in combination for patients
Categories: MAP Kinase Kinase 1, antagonists & inhibitors, Antineoplastic and Immunomodulating AgentsProducts: MEKTOVI® 15 MG TABLETAS RECUBIERTAS, Mektovı 15 mg Film Kaplı Tablet, 84 ADETVedolizumab
go.drugbank.com/drugs/DB09033ApprovedInvestigational[A261576] Vedolizumab is administered by IV infusion over a period of 30 minutes; after the first dose, it is given again at two and six weeks and then every 8 weeks thereafter. … Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: ENTYVIO® 108 MG SOLUCIÓN INYECTABLE, ENTYVIO® (SUBCUTÁNEO) VEDOLIZUMAB 108 MG SOLUCIÓN INYECTABLEMethyldopa
go.drugbank.com/drugs/DB00968ApprovedInvestigational[A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. … Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent.
Synonyms: α-methyl-L-dopa, 3-Hydroxy-alpha-methyl-L-tyrosineMixtures: Aldoril 15 Tab, Apo Methazide 15Plasma protein fraction (human)
go.drugbank.com/drugs/DB13968ApprovedInvestigationalThe composition of PPFh should be 5% of protein from which 83% should consist of albumin and no more of 17% should be globulin. … It is also stated that no more than 1% of the total protein should be gamma globulin.[L2260] PPFh is a sterile, frozen solution of solvent/detergent treated human plasma.
Mixtures: Varitect CP 25 I.E./ml InfusionslösungCategories: Amino Acids, Peptides, and ProteinsTenofovir alafenamide
go.drugbank.com/drugs/DB09299ApprovedInvestigational[A178327] Tenofovir alafenamide is indicated to treat chronic hepatitis B,[L6241] treat HIV-1,[L4388,L6277,L6280,L6283] and prevent HIV-1 infections. … [L4388,L9010] Tenofovir alafenamide was developed by Gilead Sciences Inc and granted FDA approval on 5 November 2015.[L6271]
Mixtures: GENVOYA FILM COATED TABLET 150 MG/150 MG/200 MG/10 MG, DESCOVY (200/10 MG)Categories: Vitamin B Complex, Cytochrome P-450 SubstratesSotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigationalSotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. … [L34288] This mutation makes up >50% of all KRAS mutations.[A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s.
Synonyms: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one, Kras G12C inhibitor 9Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsEdetate calcium disodium anhydrous
go.drugbank.com/drugs/DB14598ApprovedInvestigationalEdetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. … [A204173] Edetate calcium disodium was granted FDA approval on 16 July 1953.[L12774]
Categories: Diet, Food, and Nutrition, Cytochrome P-450 CYP3A InhibitorsProducts: LIBENTA AMPUL 2ML, 10 ADET, Calcium Disodium Versenate Liq 200mg/mlVismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigational[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. … Afterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells.
Synonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating Agents