Edetate calcium disodium

DB14598ApprovedInvestigationalSmall moleculeLead Chelator

Edetate calcium disodium is a chelating agent used to treat lead poisoning. It is on the World Health Organization Model List of Essential Medicines.

Mechanism: Edetate calcium disodium distributes into tissues, such as the kidney and bone, where it chelates lead ions. The lead ions are then eliminated in the normal urinary excretion of edetate. Lead in certain tissues such as the liver and bone, redistribute to other tissues after edetate calcium disodium treatment, but lead levels do not decrease to levels seen in unexposed patients.
Curator reviewed · 5 references
Primary indication: Edetate calcium disodium is indicated to reduce blood levels and depot stores of lead in acute and chronic lead poisoning.Curator reviewed · 1 structured indication
Formula / weight: C₁₀H₁₂CaN₂Na₂O₈ · 374.268 g/mol (avg)
First approval: Canada, 1993 · United States, 2009
Also known as: Edetic acid calcium disodium salt
Brand names: Calcium Disodium Versenate

Resolves to

Compound

UNII8U5D034955CAS62-33-9ChEMBLCHEMBL1200375ChEBI4757PubChem6109

Clinical / RWD

RxNorm1371967

Structure

InChIKeySHWNNYZBHZIQQV-UHFFFAOYSA-JSMILES[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5Drug interactionsStructured to mechanism, not free text

8Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

3ContraindicationsEach with its own population and attribute set

12Marketed productsAcross 5 countries and 10 labellers

20+ReferencesStructured and connected to the statements they support

Which other approved drugs treat the same conditions as Edetate calcium disodium, and which companies have late-stage candidates in those indications?

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