Search
Dacomitinib
go.drugbank.com/drugs/DB11963ApprovedInvestigationalbinding at the ATP domain of the epidermal growth factor receptor family kinase domains. … [A40009] Dacomitinib was developed by Pfizer Inc and approved by the FDA on September 27, 2018.
Products: VIZIMPRO FILM-COATED TABLET 15MG, VIZIMPRO FILM-COATED TABLET 45MGVarenicline
go.drugbank.com/drugs/DB01273ApprovedInvestigationalIn addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. … The FDA said it is keeping the black box in place at least until the results of the trial are announced.
Mixtures: PMS-varenicline, PMS-vareniclineProducts: Champix Tablet 1mg, PMS-vareniclineItraconazole
go.drugbank.com/drugs/DB01167ApprovedInvestigationalWhile the intravenous formulation of the drug was formerly available, it was discontinued in the US in 2007.[A263232] … [A34257] It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers.
Products: Itrafungol Oral Solution 10mg/ml, JAMP ITRACONAZOLE ORAL SOLUTION 10MG/MLAsciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigational[A241065] Asciminib is unique in that it acts as an allosteric inhibitor, binding at the myristoyl pocket of the BCR-ABL1 protein and locking it into an inactive conformation. … [L39005] It has also shown benefit in Ph+ CML with the T315I mutation, which produces a mutant BCR-ABL1 which is typically treatment-resistant as compared to wild-type BCR-ABL1.
Products: Scemblix 20mg film-coated tablet, Scemblix 40mg film-coated tabletDapagliflozin
go.drugbank.com/drugs/DB06292ApprovedInvestigationalDapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. … [L48251] It was later approved to reduce the risk of kidney function decline, kidney failure, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease in April
Mixtures: XIGDUO XR TABLETS 10MG/500MG, XIGDUO XR TABLETS 10MG/1000MGProducts: FORXIGA TABLET 10mg, FORXIGA 10MG FILM-COATED TABLETPancuronium
go.drugbank.com/drugs/DB01337ApprovedAs a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
Products: Pavulon Inj 1mg/ml, Pancuronium Bromide 1mg/mlAmoxapine
go.drugbank.com/drugs/DB00543ApprovedAmoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an a...
Products: Asendin - Tab 25mg, Asendin Tab 25mgEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnIt has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. … It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions.
Products: Brevibloc Liq IV 10mg/ml, Brevibloc Injection 10mg/mlButorphanol
go.drugbank.com/drugs/DB00611ApprovedIllicitVet approvedIt is used in the management of severe pain.
Products: Stadol NS - 10mg/ml Aem-liq, PMS-butorphanolBendamustine
go.drugbank.com/drugs/DB06769ApprovedInvestigationalIt is active against both active and quiescent cells, although the exact mechanism of action is unknown. … Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.
Products: BENDARED (Bendamustine Hydrochloride concentrate for solution for infusion 180mg/4mL), BENDAMUSTINA EG