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Dasatinib
go.drugbank.com/drugs/DB01254ApprovedInvestigationalBCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the pathogenesis of CML and 15-30% of ALL cases. … [A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesSynonyms: N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamidePropofol
go.drugbank.com/drugs/DB00818ApprovedInvestigationalVet approvedPropofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. … Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries
Mixtures: Anesthesia S/I-50, Anesthesia S/I-60Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsBenmelstobart
go.drugbank.com/drugs/DB17473InvestigationalAPL 502 is a humanised immunoglobulin G1 (IgG1) monoclonal antibody targeting the programmed cell death-1 ligand-1 (PD-L1).
Synonyms: gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*01 (78.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, Immunoglobulin G1 [264-alanine], anti-(human programmed death-ligand 1) (human-Mus musculus monoclonal CBT-502 γ1-chain), disulfide with human-Mus musculus monoclonal CBT-502 κ-chain, dimerPemetrexed
go.drugbank.com/drugs/DB00642ApprovedInvestigationalIts use in non-small cell lung cancer has also been investigated. Pemetrexed was first approved by the FDA in February 4, 2004.[A253907] … It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: PEMETREXED EG, Pemetrexed Actavis 100 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungSodium chloride
go.drugbank.com/drugs/DB09153ApprovedInvestigationalVet approvedSodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines. … Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions.
Mixtures: CLORURO DE POTASIO 20 MEQ EN SODIO CLORURO 0.9 % POR 100 ML, CLORURO DE POTASIO 20 MEQ EN CLORURO DE SODIO 0.9% SOLUCIÓN INYECTABLE USP 500 MLProducts: CLORURO DE SODIO AL 0.9% EN AGUA INYECTABLE, CLORURO DE SODIO AL 0.9% EN AGUA INYECTABLE BAXTERSpironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigational[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243] … It binds to mineralocorticoid receptors and functions as aldosterone antagonists.[A178192] It promotes sodium and water excretion and potassium retention.
Mixtures: SEMİTONE 50/20 MG FILM TABLET, 10 ADET, SEMİTONE 100/20 MG FILM TABLET, 10 ADETCategories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme InhibitorsMagrolimab
go.drugbank.com/drugs/DB16225InvestigationalMagrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer).
Synonyms: Immunoglobulin g4-kappa, anti-(homo sapiens cd47 (integrin associated protein, iap, mer6, oa3)), monoclonal antibodygamma4 heavy chain (1-444) (vh (homo sapiens ighv1-3*01 (87.8%)-(ighd)-ighj4*01 (100%, )) (8.8.10) (1-117)-homo sapiens ighg4*01 (ch1 (118-2Dimenhydrinate
go.drugbank.com/drugs/DB00985ApprovedInvestigational[L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline. … Dimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950.
Mixtures: Arlevert 20 mg/40 mg TablettenCategories: Heterocyclic Compounds, 2-RingCiprofloxacin
go.drugbank.com/drugs/DB00537ApprovedInvestigational[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.[L6463] … [A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.
Mixtures: ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADET, ORNISASIN 500 MG/500 MG FILM TABLET, 10 ADETCategories: MATE 2 Inhibitors, Heterocyclic Compounds, 2-RingFlurbiprofen
go.drugbank.com/drugs/DB00712ApprovedInvestigationalFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, os...
Mixtures: FULDUO 100 MG/8 MG FİLM KAPLI TABLET, 14 ADET, MULTIFLEX 200/8 MG SR KAPSUL, 14 ADETCategories: Non COX-2 selective NSAIDS, Cytochrome P-450 Substrates