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Displaying results 321 - 330 of 10000 in total
  1. Drug

    Galidesivir

    go.drugbank.com/drugs/DB11676
    Investigational

    [L12042] Because of its activity against other coronaviruses, it may be studied as a potential therapy for COVID-19. … Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: Immucillin A, Immucillin-A
  2. Drug

    Rutamycin

    go.drugbank.com/drugs/DB19908
    Experimental

    Rutamycin has a monoisotopic molecular weight of 776.51 Da. … Rutamycin is a small molecule drug. The usage of the INN stem '-mycin' in the name indicates that Rutamycin is a antibiotic, produced by Streptomyces strain.

    Synonyms: Rutamycin a, 26-demethyloligomycin a
  3. Drug

    Tividenofusp alfa

    go.drugbank.com/drugs/DB17628
    ApprovedInvestigational

    Hunter syndrome is a rare, X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2-sulfatase (IDS), which leads to the toxic accumulation of glycosaminoglycans (GAGs) throughout … Tividenofusp alfa is a recombinant human IDS fused to a monoclonal antibody that targets the human insulin receptor (HIR), utilizing receptor-mediated transcytosis to gain access to the central nervous

    Synonyms: 676>S, L 678>A, Y, - L-iduronate sulfate sulfatase, EC:3.1.6.13) pro-protein (1-525), fused via the peptide linker 526 GGGGS 530 to a human immunoglobulin G1 C-terminal Fc fragment (531-757) variant (L 544>A, L 545>A, T
  4. Drug

    Tofersen

    go.drugbank.com/drugs/DB14782
    ApprovedInvestigational

    Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 gene that causes amyotrophic lateral sclerosis (ALS). … [A259028,A259033] Tofersen was granted accelerated approval from the FDA on April 25, 2023, as the first treatment for adults with ALS caused by SOD1 mutation.

    Synonyms: DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SP, -(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))R
  5. Drug

    Carbomycin

    go.drugbank.com/drugs/DB11383
    ExperimentalVet approved

    This antibacterial is obtained from _Streptomyces halstedii_ and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains.

    Synonyms: Carbomycin A, Magnamycin ACategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  6. Drug

    Silibinin

    go.drugbank.com/drugs/DB09298
    Investigational

    Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. … Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin

    Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingSynonyms: Silibinin A, Silybin A
  7. Drug

    Meningococcal polysaccharide vaccine group Y

    go.drugbank.com/drugs/DB13888
    ApprovedInvestigational

    *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. … It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup Y.

    Synonyms: Neisseria meningitidis group Y polysaccharide antigen, A, Meningococcal polysaccharide antigen group YMixtures: Menomune-A/c/y/w-135, Menomune-A/c/y/w-135
  8. Drug

    A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor

    go.drugbank.com/drugs/DB02090
    Experimental

    Synonyms: A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor
  9. Drug

    1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE

    go.drugbank.com/drugs/DB07435
    Experimental

    Synonyms: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE
  10. Drug

    Echinomycin

    go.drugbank.com/drugs/DB15582
    Experimental

    Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from _Streptomyces echinatus_ that binds to DNA and inhibits RNA synthesis.

    Categories: Heterocyclic Compounds, 2-RingSynonyms: Quinomycin A