Silibinin

DB09298InvestigationalSmall molecule

Silibinin is a flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis. Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others.

Chemical structure of Silibinin
Primary indication
Currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.Curator reviewed · 14 structured indications
Formula / weight
C25H22O10 · 482.441 g/mol (avg)
Also known as
Silibinin A · Silybin · Silybin A · Silymarin I

Resolves to

Compound
UNII33X338MNE4CAS22888-70-6ChEMBLCHEMBL431701ChEBI9144PubChem31553KEGGD08515
Clinical / RWD
RxNorm155067PharmGKBPA166129539
Structure
InChIKeySEBFKMXJBCUCAI-HKTJVKLFSA-NSMILES[H][C@@]1(OC2=C(O[C@@H]1CO)C=CC(=C2)[C@@]1([H])OC2=C(C(O)=CC(O)=C2)C(=O)[C@@H]1O)C1=CC(OC)=C(O)C=C1
Targets
P09917ALOX5
Transporters
Q4U2R8SLC22A6Q9Y6L6SLCO1B1Q9NPD5SLCO1B3O94956SLCO2B1

What you can answer from here — as of July 17, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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4TransportersSubstrate / inhibitor direction, not just membership
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299Drug interactionsStructured to mechanism, not free text
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70Clinical trialsPhase, status and sponsor resolved per trial
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14Structured indicationsCondition, population, route and combination as fields, not prose
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3ContraindicationsEach with its own population and attribute set
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53Marketed productsAcross 4 countries and 34 labellers
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6+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Silibinin, and which of those have an active Phase 3 trial?

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