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Displaying results 3291 - 3300 of 10000 in total
  1. Drug

    Osimertinib

    go.drugbank.com/drugs/DB09330
    ApprovedInvestigational

    Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs due to the presence of specific activating EGFR mutations within the tumour cells. … In contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease.

    Synonyms: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamideCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates with a Narrow Therapeutic Index
  2. Drug

    Etonogestrel

    go.drugbank.com/drugs/DB00294
    ApprovedInvestigational

    Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.

    Mixtures: NUVARING VAGINAL HALKA, 1 ADET, Perlinring 0,120 mg/0,015 mg pro 24 Stunden - VaginalringCategories: Hormonal Contraceptives for Systemic Use
  3. Drug

    Reteplase

    go.drugbank.com/drugs/DB00015
    ApprovedInvestigationalWithdrawn

    Three domains are deleted from retavase - kringle-1, finger, and epidermal growth factor (EGF). … Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA.

    Synonyms: Human t-PA (residues 1-3 and 176-527)Products: RAPILYSIN 10 U IV ENJ. ICIN STERIL LIYOFILIZE TOZ ICEREN FLAKON, 2 ADET
  4. Drug

    Tinzaparin

    go.drugbank.com/drugs/DB06822
    ApprovedInvestigational

    Tinzaparin is composed of molecules with and without a special site for high affinity binding to antithrombin III (ATIII). This complex greatly accelerates the inhibition of factor Xa. … It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons.

    Products: INNOHEP INJECTION 14, 000 Anti-Xa IU/0.7ml, INNOHEP INYECTABLE VIAL 2 MG 10.000 UI/ML.
  5. Drug

    Hemin

    go.drugbank.com/drugs/DB03404
    ApprovedInvestigational

    More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsProducts: Normosang 25 mg/ml - Konzentrat zur Herstellung einer Infusionslösung, PANHEMATIN® POLVO ESTERIL LIOFILIZADO PARA INYECCIÓN 350 MG/ VIAL
  6. Drug

    Misoprostol

    go.drugbank.com/drugs/DB00929
    ApprovedInvestigational

    Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions.

    Mixtures: ARTHROTEC 75 MG 10 TABLET, DIFEMIS 50 MG/0.2 MG TABLET, 20 ADETCategories: Drugs for Acid Related Disorders, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)
  7. Drug

    Cariprazine

    go.drugbank.com/drugs/DB06016
    ApprovedInvestigational

    [A247100] It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. … [L41670] It is currently used to treat schizophrenia, and manic or mixed episodes and depressive episodes associated with bipolar I disorder.[L41655,L40198]

    Synonyms: trans-N-{4-[2-[4-(2,3-dichlorophenyl)piperazine-1-yl]ethyl]cyclohexyl}-N’,N’-dimethylurea hydrochlorideCategories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Chloric acid

    go.drugbank.com/drugs/DB14150
    Approved

    Categories: Compounds used in a research, industrial, or household settingProducts: Aquacid-100, Aquacid-120
  9. Drug

    Drospirenone

    go.drugbank.com/drugs/DB01395
    ApprovedInvestigational

    Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. … Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events.

    Mixtures: LÍA, Lo-ZumandimineCategories: Hormonal Contraceptives for Systemic Use
  10. Drug

    Alpha-1-proteinase inhibitor

    go.drugbank.com/drugs/DB00058
    ApprovedInvestigational

    Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

    Categories: Human alpha-1 Proteinase InhibitorSynonyms: Alpha-1 MP, .-1 protease inhibitor