Etonogestrel is a long-acting synthetic derived progestin contraceptive used in various devices such as contraceptive rings and intradermal implants. Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.
- Mechanism
- Curator reviewed · 2 references
Etonogestrel binds with high affinity to the progesterone receptors in the target organs. From the target organs, they include the female reproductive tract, mammary gland, hypothalamus, and pituitary. Once bound, this drug changes the synthesis of different proteins which in order decreases the level of gonadotropin-releasing hormone and the luteinizing hormone. There is no evidence that etonogestrel has affinity for estrogen receptors.
- Primary indication
- Etonogestrel is administered in subdermal implants as long-acting reversible contraception.Curator reviewed · 3 structured indications
- Formula / weight
- C22H28O2 · 324.4565 g/mol (avg)
- First approval
- Canada, 2021 · United States, 2001
- Also known as
- 3-Ketodesogestrel · 3-Oxodesogestrel
- Code names
- ORG-3236
- Brand names
Resolves to
GCKFUYQCUCGESZ-BPIQYHPVSA-NSMILES[H][C@@]12CC[C@@](O)(C#C)[C@@]1(CC)CC(=C)[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]What you can answer from here — as of September 23, 2026
Which drugs share a target with Etonogestrel, and which of those have an active Phase 3 trial?
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