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Reboxetine
go.drugbank.com/drugs/DB00234ApprovedInvestigationalWithdrawnReboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesEthynodiol diacetate
go.drugbank.com/drugs/DB00823ApprovedA synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCyclophosphamide
go.drugbank.com/drugs/DB00531ApprovedInvestigationalPrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersQuinethazone
go.drugbank.com/drugs/DB01325ApprovedQuinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.
Chlorothiazide
go.drugbank.com/drugs/DB00880ApprovedInvestigationalVet approvedA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Zavegepant
go.drugbank.com/drugs/DB15688ApprovedInvestigationalDue to its pharmacological properties, it can be administered intranasally.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBenfluorex
go.drugbank.com/drugs/DB09022ApprovedWithdrawnBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier.
Tranexamic acid
go.drugbank.com/drugs/DB00302ApprovedInvestigationalTranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding.
Phloxine B
go.drugbank.com/drugs/DB13911ApprovedWithdrawnPhloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing
Synonyms: D&C Red No. 28Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsLight green SF yellowish
go.drugbank.com/drugs/DB11183ApprovedAlthough it has been used as a food colorant, it was discontinued from the market due to low popularity which are possibly due to low durability of the dye and increased tendency of the dye to fade.
Categories: P-glycoprotein inhibitors