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Benziodarone
go.drugbank.com/drugs/DB13277ApprovedWithdrawnIt was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T487, A175636].
Cytarabine
go.drugbank.com/drugs/DB00987ApprovedInvestigationalCytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 1-beta-D-Arabinofuranosylcytosine, cytosine-β-D-arabinofuranosideAcenocoumarol
go.drugbank.com/drugs/DB01418ApprovedInvestigationalAcenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 3-(alpha-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin, 3-(alpha-(p-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarinCenobamate
go.drugbank.com/drugs/DB06119ApprovedInvestigationalCenobamate, or YKP-3089, is an antiepileptic drug developed by SK Pharmaceuticals and used to treat partial onset seizures.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnTropisetron is an indole derivative with antiemetic activity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesTilbroquinol
go.drugbank.com/drugs/DB13222ApprovedTilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit [L5467].
Fallypride
go.drugbank.com/drugs/DB15167InvestigationalFallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans).
Categories: Dopamine D2 Receptor AntagonistsTemsirolimus
go.drugbank.com/drugs/DB06287ApprovedInvestigationalTemsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the E...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesIsoniazid
go.drugbank.com/drugs/DB00951ApprovedInvestigationalAntibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsPolythiazide
go.drugbank.com/drugs/DB01324ApprovedA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)