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Displaying results 3331 - 3340 of 10000 in total
  1. Drug

    Estradiol dienanthate

    go.drugbank.com/drugs/DB13955
    ApprovedVet approvedWithdrawn

    Estradiol is commonly produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10%). … First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a chance to enter systemic circulation and exert its estrogenic effects [A12102].

    Categories: Cytochrome P-450 CYP1A1 Substrates, Cytochrome P-450 Substrates
  2. Drug

    Tasimelteon

    go.drugbank.com/drugs/DB09071
    ApprovedInvestigational

    By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism … In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  3. Target

    E3 ubiquitin-protein ligase HUWE1

    go.drugbank.com/bio_entities/BE0016469
    TargetHumans

    Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). … Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542).

    Synonyms: Homologous to E6AP carboxyl terminus homologous protein 9
  4. Drug

    Obeticholic acid

    go.drugbank.com/drugs/DB05990
    ApprovedInvestigational

    [L34650] Obeticholic acid is currently being considered for FDA approval to treat fibrosis caused by non-alcoholic liver steatohepatitis (NASH). … hepatic decompensation) due to a risk of liver failure, in some cases requiring liver transplantation.

    Synonyms: (3α,5β,6α,7α)-6-ethyl-3,7-dihydroxycholan-24-oic acidCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  5. Drug

    Rose bengal

    go.drugbank.com/drugs/DB11182
    ApprovedInvestigational

    The clinical applications of rose bengal as injectable formulation under the name PV-10 in melanoma, breast cancer and skin conditions such as eczema and psoriasis are being investigated in clinical trials … Its disodium salt in ophthalmic solutions has been used as a diagnostic agent in suspected damage to conjunctival and corneal cells.

  6. Drug

    Voxelotor

    go.drugbank.com/drugs/DB14975
    Approved

    to 20 million others worldwide. … [L10403] It was developed by Global Blood Therapeutics, Inc.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Substrates
  7. Drug

    ME-344

    go.drugbank.com/drugs/DB13062
    Investigational

    ME-344 has been used in trials studying the treatment of Solid Tumors.

  8. Drug

    Suplatast

    go.drugbank.com/drugs/DB19138
    Investigational

    Suplatast is under investigation in clinical trial NCT05983471 (Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF)).

  9. Drug

    Levoketoconazole

    go.drugbank.com/drugs/DB05667
    Approved

    [A244083, A29319, L39573] Levoketoconazole was approved by the FDA on December 30, 2021, and is currently marketed under the registered trademark RECORLEV by Xeris Pharmaceuticals, Inc.[L39563] … [A244078, A244083] [Ketoconazole] has been used both on- and off-label to treat CS due to its ability to inhibit cortisol production.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers
  10. Drug

    LG-100268

    go.drugbank.com/drugs/DB01941
    Experimental

    LG-100268 is a retinoid X receptor (RXR) selective compound.