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Cixutumumab
go.drugbank.com/drugs/DB12250InvestigationalCixutumumab is a highly specific recombinant human monoclonal antibody with high affinity for the insulin-like growth factor-I receptor (IGF-IR). IGF-IR is overexpressed in a variety of tumour types.
Categories: Receptor, IGF Type 1Vadadustat
go.drugbank.com/drugs/DB12255ApprovedInvestigationalOne of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability of the kidney to respond to anemic conditions with a corresponding increase in [erythropoietin] (EPO … [A244165] A relatively new and alternative treatment option for patients with anemia associated with CKD is the use of small molecule inhibitors of hypoxia-inducible factor prolyl-hydroxylase (HIF-PH
Synonyms: Glycine, N-((5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl)carbonyl)-, N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycineCategories: Cytochrome P-450 CYP2B6 Inducers, Heterocyclic Compounds, 1-RingRadiprodil
go.drugbank.com/drugs/DB12260InvestigationalRadiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.
Categories: Heterocyclic Compounds, 1-RingAtevirdine
go.drugbank.com/drugs/DB12264InvestigationalAtevirdine has been used in trials studying the treatment of HIV Infections.
Categories: Heterocyclic Compounds, 1-RingFexinidazole
go.drugbank.com/drugs/DB12265ApprovedHuman African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per … Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first (hemolymphatic) stage that progresses to a second (meningoencephalitic) stage in which patients experience progressively
Categories: MATE 2-K Inhibitors, MATE 1 InhibitorsEpofolate
go.drugbank.com/drugs/DB12266InvestigationalEpofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target folate receptor expressing cancer cells. … and neutropenia appear to have been less frequent and less severe as compared to epothilones.
Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 2-RingAducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigationalin amyloid-β plaques. … Aducanumab, or BIIB037, is a monoclonal IgG1 antibody that targets extracellular amyloid-β plaques in the brain; similar to [gantenerumab], [bapineuzumab] and [solanezumab].
Polihexanide
go.drugbank.com/drugs/DB12277ApprovedInvestigationalPolihexanide, also known as polyhexamethylene biguanide (PHMB), is a broad-spectrum antimicrobial polymer primarily used for topical antisepsis and wound management. … [A1351] It is effective against a wide range of Gram-positive and Gram-negative bacteria.
Mixtures: Ucheer CCategories: Compounds used in a research, industrial, or household settingAZD-5423
go.drugbank.com/drugs/DB12280InvestigationalAZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDarexaban
go.drugbank.com/drugs/DB12289InvestigationalDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
Categories: Heterocyclic Compounds, 1-Ring