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Siltuximab
go.drugbank.com/drugs/DB09036ApprovedInvestigationalSiltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound I...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersCeritinib
go.drugbank.com/drugs/DB09063ApprovedInvestigationalCeritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% o...
Categories: Receptor Protein-Tyrosine Kinases, antagonists & inhibitors, P-glycoprotein substratesCobicistat
go.drugbank.com/drugs/DB09065ApprovedInvestigationalCobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by in...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTasimelteon
go.drugbank.com/drugs/DB09071ApprovedInvestigationalTasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD).
Categories: Melatonin Receptor Agonists, Cytochrome P-450 SubstratesBrexpiprazole
go.drugbank.com/drugs/DB09128ApprovedInvestigationalCompared to aripiprazole, brexpiprazole has less potential for partial agonist-mediated adverse effects such as extrapyramidal symptoms, which is attributed to lower intrinsic activity at the D2 receptor
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTechnetium Tc-99m tetrofosmin
go.drugbank.com/drugs/DB09160ApprovedTechnetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and w...
Categories: P-glycoprotein substratesEtizolam
go.drugbank.com/drugs/DB09166InvestigationalEtizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxio...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesButyrfentanyl
go.drugbank.com/drugs/DB09173ExperimentalIllicitButyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug. It is an analog of fentanyl with roughly 1/30 the potency. Butyrfentanyl was first synthesized in 1961 ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesRivoglitazone
go.drugbank.com/drugs/DB09200InvestigationalRivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsAzelnidipine
go.drugbank.com/drugs/DB09230InvestigationalAzelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increa...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates