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Rindopepimut

Rindopepimut (CDX-110) is an injectable peptide cancer vaccine which targets a mutant protein called EGFRvIII present in about 25% to 30% of glioblastoma cases. … The US FDA granted it Breakthrough Therapy Designation for glioblastoma in Feb 2015.

Paramethasone

(From Martindale, The Extra Pharmacopoeia, 30th ed, p737) … It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less

Isavuconazole

It is proposed that the intravenous and oral dosing can be used interchangeably [L1482], without the need for a repeat loading dose when transitioning from an IV to an oral formulation [A32026]. … Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile [A32026].

Enbucrilate

Enbucrilate is under investigation in clinical trial NCT02468206 (Secondary Prophylaxis of Gastric Variceal Bleed).

Tipapkinogene sovacivec

Pheniprazine

Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. … In addition, it was used for the treatment of other conditions, such as angina pectoris and schizophrenia.

Theobromine

(From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9) … It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension.

Triethylhexanoin

Triethylhexanoin is an ingredient of cosmetic products as a fragrant solvent.

Duvelisib

[A39025] Duvelisib was developed by Verastem, Inc and FDA approved on September 24, 2018.[L4585]

Astodrimer

Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups.