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Pemigatinib
go.drugbank.com/drugs/DB15102ApprovedInvestigationalPemigatinib is marketed under the brand name Pemazyre, and it is available as oral tablets.[L13050] … [L13068] Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy.
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesHydroxyethyl Starch
go.drugbank.com/drugs/DB09106ApprovedInvestigationalHES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose. … Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.
Mixtures: VOLUVEN 6%, VOLUVEN 6%Categories: Compounds used in a research, industrial, or household settingMethylcellulose
go.drugbank.com/drugs/DB11228ApprovedInvestigationalThe Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values … It is available under a variety of trade names as a treatment for constipation. Like cellulose, it is not digestible, not toxic, and not allergenic
Categories: Compounds used in a research, industrial, or household settingProducts: Murocel Liq 1%, Best Choice Fiber TherapyLepirudin
go.drugbank.com/drugs/DB00001ApprovedWithdrawn[A3, L41539] HIT is caused by the expression of immunoglobulin G (IgG) antibodies that bind to the complex formed by heparin and platelet factor 4. … [L41539] Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the substitution of leucine for isoleucine
Synonyms: R-hirudin, Hirudin variant-1Copanlisib
go.drugbank.com/drugs/DB12483ApprovedInvestigationalCopanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. … [A261730] Copanlisib was granted accelerated approval by the FDA in September 2017 for the treatment of follicular lymphoma.[A261725]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 2-AMINO-N-(7-METHOXY-8-(3-(MORPHOLIN-4-YL)PROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL(PYRIMIDINE-5-CARBOXAMIDE, 2-AMINO-N-(7-METHOXY-8-(3-MORPHOLIN-4-YLPROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL)PYRIMIDINE-5-CARBOXAMIDEPancrelipase amylase
go.drugbank.com/drugs/DB11065ApprovedInvestigational[T177] The pancrelipase amylase is a single polypeptide chain containing two SH groups and four disulfide bridges. … [L2509] The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch into more available saccharide forms.
Mixtures: Creon 8 Cap, Cotazym Ecs 8Synonyms: Amylase A, 1,4-alpha-D-Glucan glucanohydrolaseEugenol
go.drugbank.com/drugs/DB09086ApprovedInvestigationalIts exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction. … There are a number of unapproved OTC products available containing eugenol that advertise its use for the treatment of toothache.
Categories: Compounds used in a research, industrial, or household settingCX-052075
go.drugbank.com/drugs/DB31655ApprovedCX-052075 is a nucleoside-modified messenger RNA (mRNA) encoding the N-terminal domain (NTD) and receptor-binding domain (RBD) of the spike glycoprotein of the SARS-CoV-2 Omicron variant sublineage LP.8.1 … the SARS-CoV-2 spike protein, allowing for a more targeted immune response and the use of a significantly smaller amount of mRNA per dose.
Barnidipine
go.drugbank.com/drugs/DB09227InvestigationalThe active component is composed of a single optical isomer (*3'S, 4S* configuration), which is the most potent and longest-acting of the four enantiomers [A31567]. … after a 1-year and 2-year follow-up period in 91% of the patients who had an initial response to the drug [A7842].
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingBempedoic acid
go.drugbank.com/drugs/DB11936ApprovedInvestigational[L12144,L12147] It was developed by Esperion Therapeutics Inc. and approved by the FDA on February 21, 2020. … Caused by genetic mutations or lifestyle factors, hypercholesterolemia can significantly reduce quality of life and increase the risk of mortality from cardiovascular disease.