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Integrin alpha-M
go.drugbank.com/bio_entities/BE0010412TargetHumansMay regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). … It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b.
Synonyms: Cell surface glycoprotein MAC-1 subunit alpha, Neutrophil adherence receptorAllylestrenol
go.drugbank.com/drugs/DB01431InvestigationalIt is widely marketed throughout Europe, including Russia and many other European countries, and is also available in Japan, Hong Kong, India, Bangladesh, Indonesia, and much of Southeast Asia, though
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesRevumenib
go.drugbank.com/drugs/DB18515ApprovedInvestigational[A264688] Revumenib is an oral small molecule menin inhibitor that prevents the interaction between menin and aberrant KMT2A. … [L51888] In October of 20225, it was approved for myeloid leukemia patients with nucleophosmin 1 (NPM1) mutations. [L54376]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsAvutometinib
go.drugbank.com/drugs/DB15254ApprovedInvestigational[A273948] Avutometinib was approved by the US FDA in May 2025 in a co-package alongside [defactinib] (called Avmapki Fakzynja) for the treatment of recurrent KRAS-mutated low-grade serous ovarian cancer
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMestranol
go.drugbank.com/drugs/DB01357ApprovedWithdrawnIt is used as the estrogen component of many combination ORAL contraceptives.
Categories: Hormonal Contraceptives for Systemic Use, Cytochrome P-450 SubstratesPF-06751979
go.drugbank.com/drugs/DB15105InvestigationalPF-06751979 is under investigation in clinical trial NCT03126721 (The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults).
Isocarboxazid
go.drugbank.com/drugs/DB01247ApprovedIsocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder ...
Categories: Antidepressive Agents Indicated for Depression, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesTrazodone
go.drugbank.com/drugs/DB00656ApprovedInvestigationalTrazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. … used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor
Categories: Antidepressive Agents Indicated for Depression, P-glycoprotein inducersSMAD family member 2
go.drugbank.com/bio_entities/BE0004445TargetHumansMay act as a tumor suppressor in colorectal carcinoma (PubMed:8752209) … Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.
Synonyms: MAD homolog 2, Mad-related protein 2Trichlormethiazide
go.drugbank.com/drugs/DB01021ApprovedVet approvedA thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)