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Displaying results 3471 - 3480 of 5449 in total
  1. Drug

    4-Hydroxytestosterone

    go.drugbank.com/drugs/DB01485
    IllicitInvestigational

    It is specifically the 17-hydroxylated analog to formestane. … It is an anabolic steroid with no therapeutic indications, which is prohibited from use in sports by the World Anti-Doping Agency.

  2. Drug

    Vusolimogene oderparepvec

    go.drugbank.com/drugs/DB23008
    ApprovedInvestigational

    [L64061,L64062] It is the second oncolytic viral therapy approved in the United States, following talimogene laherparepvec (T-VEC, Imlygic) in 2015, and the first approved for melanoma that has progressed … [L64061] It is administered by direct injection into superficial, deep, or visceral tumors.

  3. Drug

    Dipyrithione

    go.drugbank.com/drugs/DB11327
    Approved

    [L2611] It is currently used as a pesticide, and not used in any FDA approved drug products. … [A32825] It may be combined with other ingredients, such as triclosan to serve as antifungal and antibacterial skin treatments.

  4. Drug

    Lesinurad

    go.drugbank.com/drugs/DB11560
    ApprovedWithdrawn

    It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with … Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with gout in patients who have not achieved target

  5. Drug

    Luspatercept

    go.drugbank.com/drugs/DB12281
    ApprovedInvestigational

    [A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients with beta thalassemia who require regular blood … [L42455] Luspatercept is novel in that it ameliorates anemia via action on late-stage erythropoiesis, in contrast to typical erythropoiesis-stimulating agents (ESAs), such as [darbepoetin alfa] and [epoetin

    Products: Reblozyl 25 mg powder for solution for injection, Reblozyl 75 mg powder for solution for injection
  6. Drug

    NOX-700

    go.drugbank.com/drugs/DB05464
    Experimental

    It has since been found that oxidative signaling of the redox-sensitive transcription factor, NF-κB, and inhibiting protein glycation are responsible for the drug's therapeutic effects.

  7. Drug

    Metrizamide

    go.drugbank.com/drugs/DB01578
    Experimental

    It is also used as a resorbable, non-ionic contrast medium.

  8. Drug

    Cryptenamine

    go.drugbank.com/drugs/DB00785
    Approved

    It has been used in the treatment of hypertension but has largely been replaced by drugs with fewer adverse effects.

  9. Drug

    PRO 2000

    go.drugbank.com/drugs/DB05385
    Investigational

    It is being studied for the prevention of HIV infection and other sexually transmitted diseases. … PRO 2000 is an investigational medicine that is not yet approved by the FDA for use outside of clinical trials.

  10. Drug

    Dactinomycin

    go.drugbank.com/drugs/DB00970
    ApprovedInvestigational

    It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release.

    Products: DACTINOMYCIN FOR INJECTION 0.5 mg/vial