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Displaying results 341 - 350 of 2828 in total
  1. Target

    H(+)/Cl(-) exchange transporter 3

    go.drugbank.com/bio_entities/BE0013365
    TargetHumans

    The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874).

    Polypeptides: H(+)/Cl(-) exchange transporter 3Synonyms: Chloride transporter ClC-3
  2. Drug

    Vortioxetine

    go.drugbank.com/drugs/DB09068
    ApprovedInvestigational

    More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B … Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional

    Categories: Membrane Transport Modulators
  3. Drug

    Narsoplimab

    go.drugbank.com/drugs/DB16418
    ApprovedInvestigational

    [A241030, A241040] Narsoplimab (OMS721), a human IgG4λ anti-MASP-2 antibody, is under consideration as a treatment for hematopoietic stem cell transplant-associated TMA (HSCT-TMA/TA-TMA) and IgA nephropathy … [A241045, A241050] Approved by the FDA on December 24, 2025, narsoplimab-wuug is indicated for the treatment of hematopoietic stem cell transplant–associated thrombotic microangiopathy (TA-TMA) in adults

  4. Drug

    Tivanisiran

    go.drugbank.com/drugs/DB19105
    Investigational

    Tivanisiran is under investigation in clinical trial NCT03108664 (HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED)).

    Synonyms: Rna, (a-a-g-c-g-c-a-u-c-u-u-c-u-a-c-u-u-c-a), complex with rna (u-g-a-a-g-u-a-g-a-a-g-a-u-g-c-g-c-u-u) (1:1)
  5. Drug

    Eleuthero

    go.drugbank.com/drugs/DB14303
    ApprovedInvestigational

    Eleuthero is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Synonyms: Acanthopanacis Senticosi Radix Et Rhizoma Seu CaulisCategories: Complex Mixtures
  6. Target

    Copper

    go.drugbank.com/bio_entities/BE0004825
    TargetHumans

  7. Drug

    Linerixibat

    go.drugbank.com/drugs/DB11729
    ApprovedInvestigational

    Linerixibat is a first-in-class and small-molecule inhibitor of the ileal bile acid transporter (IBAT).

    Categories: Ileal Bile Acid Transporter Inhibitor
  8. Drug

    Methyclothiazide

    go.drugbank.com/drugs/DB00232
    ApprovedWithdrawn

    A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)

    Categories: Membrane Transport Modulators, Genito Urinary System and Sex Hormones
  9. Target

    Proton-coupled amino acid transporter 1

    go.drugbank.com/bio_entities/BE0000536
    TargetTransporterHumans

    Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12527723, PubMed:12809675, PubMed:19549785). May be i...

    Polypeptides: Proton-coupled amino acid transporter 1Synonyms: Proton/amino acid transporter 1
  10. Target

    NPC1-like intracellular cholesterol transporter 1

    go.drugbank.com/bio_entities/BE0000802
    TargetTransporterHumans

    Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). … May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032).

    Polypeptides: NPC1-like intracellular cholesterol transporter 1