Proton-coupled amino acid transporter 1

BE0000536ProteinHumansSLC36A1

Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12527723, PubMed:12809675, PubMed:19549785). It is acted on by 12 drugs in DrugBank.

Gene name
SLC36A1
UniProtKB entry
Q7Z2H8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
476 residues · 53,075 Da
Also known as
hPAT1 · PAT1 · Proton/amino acid transporter 1 · Solute carrier family 36 member 1

Resolves to

Protein
UniProtQ7Z2H8UniProt nameS36A1_HUMAN
Gene
HGNCHGNC:18761NCBI Gene206358GenBank31324239GeneCardsSLC36A1
Pharmacology
IUPHAR/GtoPdb1161KEGGhsa:206358
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled amino acid transporter 1, how selective are they, and which programs against it are still in active trials?

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