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Benazepril
go.drugbank.com/drugs/DB00542ApprovedInvestigationalBenazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. … Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Mixtures: BENAZEPLUS AL 20MG/25MG, BENAZEPLUS AL 10MG/12.5MGCategories: Agents Acting on the Renin-Angiotensin SystemIsotretinoin
go.drugbank.com/drugs/DB00982ApprovedInvestigationalIsotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. … [L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Categories: Retinoids for Topical Use in AcneSynonyms: 13-RA, cis-RAIsosorbide mononitrate
go.drugbank.com/drugs/DB01020ApprovedInvestigational[L11743] Isosorbide mononitrate has a longer duration of action than [nitroglycerin] due to its slow onset of absorption and metabolism. … Like other organic nitrates, isosorbide mononitrate acts as a prodrug for its active metabolite, [nitric oxide], which mediates the therapeutic action of isosorbide mononitrate.
Categories: Vasodilators Used in Cardiac DiseasesSynonyms: IS 5-MN, IS-5-MNMethoxy polyethylene glycol-epoetin beta
go.drugbank.com/drugs/DB09107ApprovedInvestigationalMethoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin.
Categories: Compounds used in a research, industrial, or household settingProducts: MIRCERA ROCHE 30 MCG/0,3 ML SC/IV ENJ. ICIN KULLANIMA HAZIR SIRINGA, MIRCERA ROCHE 50 MCG/0,3 ML SC/IV ENJ. ICIN KULLANIMA HAZIR SIRINGAUrokinase
go.drugbank.com/drugs/DB00013ApprovedInvestigationalWithdrawn[A191943] Urokinase remains connected between these 2 chains by a sulfhydryl bond.[A191943] Urokinase was granted FDA approval on 16 January 1978.[L12138] … Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase.
Products: UROCHINASI EGBudesonide
go.drugbank.com/drugs/DB01222ApprovedInvestigational[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994.[L10598] It is also available in a combination product with [formoterol].[L10619] … Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.
Mixtures: BUDESONIDE E FORMOTEROLO SANDOZ, BUDESONIDE E FORMOTEROLO SANDOZProducts: BUDESONIDA 50 MCG INHALADOR EN AEROSOL, BUDESONIDA 100 MCG SUSPENSION ACUOSA NASAL EN AEROSOL.Zuclopenthixol
go.drugbank.com/drugs/DB01624ApprovedInvestigationalThese are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom. … Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States.
Products: CLOPIXOL DEPOT ENJ. 200 MG/ML IM SOLÜSYON, 1 ML, CLOPIXOL ACUPHASE 50 MG/ML IM ENJ. SOLUSYON, 1 MLThiotepa
go.drugbank.com/drugs/DB04572ApprovedInvestigationalIt is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. … N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N,N′,N′′-tri-1,2-ethanediyl-, Phosphorothioic triamide, N,N′,N′′-tri-1,2-ethanediyl-Penciclovir
go.drugbank.com/drugs/DB00299ApprovedDisplaying low toxicity and good selectivity, penciclovir is a nucleoside analogue. … Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections.
Products: EX-LOVIR % 1 KREM 2 GNicergoline
go.drugbank.com/drugs/DB00699ApprovedAn ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Products: NICERGOLINA EG