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Metenkefalin
go.drugbank.com/drugs/DB12668Investigational[A203210] Metenkefalin, along with [tridecactide], are under investigation as an immunomodulatory therapy for moderate to severe COVID-19.[L13874,L13877]
Categories: Experimental Unapproved Treatments for COVID-19, mu-Opioid Receptor AgonistClemastine
go.drugbank.com/drugs/DB00283ApprovedInvestigationalAn ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Categories: Antihistamines for Systemic Use, Antihistamines for Topical UseEthchlorvynol
go.drugbank.com/drugs/DB00189ApprovedIllicitWithdrawnEthchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.
Amolimogene bepiplasmid
go.drugbank.com/drugs/DB04904InvestigationalAmolimogene was biologically engineered as a targeted therapy for the treatment of cervical dysplasia.
Testolactone
go.drugbank.com/drugs/DB00894ApprovedWithdrawnAn antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
Erdosteine
go.drugbank.com/drugs/DB05057ApprovedInvestigationalIt is a _thiol_ derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis.
Primidone
go.drugbank.com/drugs/DB00794ApprovedVet approvedPrimidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 Ma...
Oveporexton
go.drugbank.com/drugs/DB21680Approved[L64069] The FDA approved oveporexton on August 5, 2026 for the treatment of narcolepsy type 1 (narcolepsy with cataplexy) in adults. … [L64069] Oveporexton has been recommended for scheduling as a controlled substance, and its final controlled-substance schedule and commercial availability are pending a determination by the Drug Enforcement
Categories: Orexin receptor agonistsmRNA-1283
go.drugbank.com/drugs/DB22668ApprovedInvestigationalpreviously approved COVID-19 mRNA vaccines, including the original [Moderna COVID-19 Vaccine], mRNA-1283 encodes only the immunodominant regions (NTD and RBD) of the SARS-CoV-2 spike protein, allowing for … [L53413,A274083] mNEXSPIKE was approved by the US FDA in June 2025 for use in patients who have been previously vaccinated with any COVID-19 vaccine and who are at a higher risk of severe outcomes from
Ensifentrine
go.drugbank.com/drugs/DB16157ApprovedInvestigational[L50903] On June 26, 2024, the FDA announced the approval of an inhaled product of ensifentrine for the treatment of chronic obstructive pulmonary disease (COPD) in adults, which allows the drug to be