Testolactone is a medication used to treat advanced breast cancer.
- Mechanism
- Curator reviewed
Although the precise mechanism by which testolactone produces its clinical antineoplastic effects has not been established, its principal action is reported to be inhibition of steroid aromatase activity and consequent reduction in estrone synthesis from adrenal androstenedione, the major source of estrogen in postmenopausal women. Based on in vitro studies, the aromatase inhibition may be noncompetitive and irreversible. This phenomenon may account for the persistence of testolactone's effect on estrogen synthesis after drug withdrawal.
- Primary indication
- For palliative treatment of advanced breast cancer in postmenopausal women.Curator reviewed
- Formula / weight
- C19H24O3 · 300.3921 g/mol (avg)
- First approval
- United States, 2009
- Also known as
- 1-dehydrotestololactone · delta(1)-testololactone
- Code names
- NSC-23759 · SQ-9538
Resolves to
BPEWUONYVDABNZ-DZBHQSCQSA-NSMILES[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)OC(=O)CC[C@@]21[H]What you can answer from here — as of September 13, 2026
Which drugs share a target with Testolactone, and which of those have an active Phase 3 trial?
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