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Valdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Zilganersen
go.drugbank.com/drugs/DB18161ApprovedInvestigational[L64096] The FDA approved zilganersen on September 3, 2026 for the treatment of Alexander disease in pediatric and adult patients, making it the first and only disease-modifying treatment for the condition
Tirapazamine
go.drugbank.com/drugs/DB04858InvestigationalTirapazamine entered phase III testing in 2006 for patients with head and neck cancer and gynecological cancer, as well as for other solid tumor cancer types. … For all these reasons, the combination of tirapazamine with other anticancer treatments is highly recommended.
SR-123781A
go.drugbank.com/drugs/DB05361InvestigationalIt is under investigation by Sanofi-Aventis and Organon for the treatment of thrombosis and acute coronary syndromes (ACS).
Borage oil
go.drugbank.com/drugs/DB11238ApprovedGLA, which accounts for approximately 24% of the oil, is converted to dihomo-γ-linolenic acid (DGLA) which acts as a precursor to anti-inflammatory mediators such as 1-series prostaglandins and the 3-series … Borage oil may be found in foods or in skin care products.
Bucetin
go.drugbank.com/drugs/DB13278ApprovedWithdrawnBucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication.[A175636]
Suprofen
go.drugbank.com/drugs/DB00870ApprovedWithdrawnIt is no longer approved for use in the United States.
ADH-1
go.drugbank.com/drugs/DB05485InvestigationalAs many tumors become more aggressive, invasive, and malignant, researchers have found that N-cadherin is expressed in greater amounts, making it an important target for developing anti-cancer treatments
WU-NK-101
go.drugbank.com/drugs/DB18350InvestigationalWU-NK-101 is an allogeneic CD3-depleted, CD56-enriched activated natural killer-cell product
MK-7145
go.drugbank.com/drugs/DB11968InvestigationalMK-7145 has been used in trials studying the treatment of Hypertension and Renal Insufficiency.