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Rifaximin
go.drugbank.com/drugs/DB01220ApprovedInvestigationalIt has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel … syndrome (IBS-D) in adult women and men.
Categories: Heterocyclic Compounds with 4 or More Rings, Cytochrome P-450 SubstratesSynonyms: Rifamycin L 105Ephedrine
go.drugbank.com/drugs/DB01364ApprovedInvestigational[A193701,A193704,L12975] Ephedrine was granted a type 7 FDA Approval on 29 April 2016.[L12975] … It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine
Mixtures: BROKSIN 6.66 MG/5 ML+100 MG/5 ML SURUP, 150 ML, COPHADYL-E COUGH LINCTUSCategories: Herbs and Natural ProductsNimesulide
go.drugbank.com/drugs/DB04743ApprovedWithdrawnNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. … Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Mixtures: ETNA COMBO 100 MG/8 MG TABLET, 14 ADET, NİMES COMBO 100 MG / 8 MG TABLET , 14 ADETCategories: Selective Cyclooxygenase 2 Inhibitors (NSAIDs), Cytochrome P-450 SubstratesCarboplatin
go.drugbank.com/drugs/DB00958ApprovedInvestigationalCarboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982. … [A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Categories: Compounds used in a research, industrial, or household settingSynonyms: Platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(SP-4-2)Mirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigational[L32853] Mirabegron is also used in other jurisdictions across the globe, including Canada,[L32925] the EU,[L32945] and Japan.[A7469] … It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significant antimuscarinic activity,[A232553] which is responsible
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 10 TABLET, BETMIGA 50 MG UZATILMIŞ SALIMLI FILM TABLET ,100 TABLETMethylergometrine
go.drugbank.com/drugs/DB00353ApprovedInvestigational(Merck Index, 11th ed)
Synonyms: 9,10-Didehydro-N-[1-(hydroxymethyl)-propyl]-D-lysergamideInternational brands: Ingagen-M, Partan MZidovudine
go.drugbank.com/drugs/DB00495ApprovedInvestigationalA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. … It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS.
Mixtures: COMBİVİR 150 MG/300 MG FİLM KAPLI TABLET, LAMIVUDINA 150 MG & ZIDOVUDINA 300 MG TABLETASCategories: Antivirals used in combination for the treatment of HIV infections, Cytochrome P-450 SubstratesBendamustine
go.drugbank.com/drugs/DB06769ApprovedInvestigationalIt is active against both active and quiescent cells, although the exact mechanism of action is unknown. … Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: BENDAMUSTINA EG, LEVACT 25 MG İNFÜZYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON , 10 ADETQuetiapine
go.drugbank.com/drugs/DB01224ApprovedInvestigationalInitially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. … It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].[A2189]
Mixtures: Quetialan 4 Tage Startpackung - Filmtabletten, Seroquel 4-Tage Startpackung FilmtablettenCategories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsTopiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigational[A175249] It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. … [L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: TOPIRAMATO EG, Topamax 50 mg Granulat in Kapseln