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Pimozide
go.drugbank.com/drugs/DB01100ApprovedA diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome.
Categories: Serotonin Receptor Antagonists, Dopamine D2 Receptor AntagonistsUmeclidinium
go.drugbank.com/drugs/DB09076ApprovedInvestigational[A7719] However, even though umeclidinium monotherapy is well-tolerated for up to 14 days, it is more likely to be used in combination therapy, as the international Gold Initiative for Chronic Obstructive … Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD).
Categories: Drugs for Obstructive Airway Diseases, Cytochrome P-450 SubstratesCA-170
go.drugbank.com/drugs/DB15772InvestigationalCA-170 is a selective, small molecule inhibitor of PD-L1.
PF-07799933
go.drugbank.com/drugs/DB17489InvestigationalPF-07799933 is a BRAF class 2 inhibitor developed by Pfizer.
Diloxanide
go.drugbank.com/drugs/DB08792ExperimentalAlthough it is not currently approved for use in the United States, it was approved by a CDC study in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990. … Diloxanide (as [Diloxanide furoate]) is an anti-protozoal drug used in the treatment of Entamoeba histolytica and some other protozoal infections.
Hydroxypropyl cellulose
go.drugbank.com/drugs/DB00840ApprovedLacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. … As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer.
Ifenprodil
go.drugbank.com/drugs/DB08954ApprovedInvestigationalWithdrawn[A196128] Ifenprodil is being investigated for its potential utility in treating COVID-19 in an ongoing phase 2b/3 clinical trial (NCT04382924).[L16343] … [A220143, A196128] In an unbiased screen for compounds capable of reducing cell death induced by infection with the influenza strain H5N1, ifenprodil was found to have a protective effect against H5N1-
Categories: Experimental Unapproved Treatments for COVID-19, NMDA Receptor AntagonistsGepirone
go.drugbank.com/drugs/DB12184ApprovedIt was not until an extended-release formulation of gepirone was made available that gepirone became a potential candidate for a new antidepressant. … Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration due to the short half-lives.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates