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Displaying results 3631 - 3640 of 10000 in total
  1. Target

    5'(3')-deoxyribonucleotidase, cytosolic type

    go.drugbank.com/bio_entities/BE0004774
    EnzymeHumans

    Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP (Ref.12).

    Polypeptides: 5'(3')-deoxyribonucleotidase, cytosolic typeSynonyms: Deoxy-5'-nucleotidase 1, Cytosolic 5',3'-pyrimidine nucleotidase
  2. Target

    5'-AMP-activated protein kinase

    go.drugbank.com/bio_entities/BE0004907
    TargetTransporterHumans

    Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:31492851, PubMed:37821951...

    Polypeptides: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit beta-2
  3. Target

    Keratin, type II cytoskeletal 5

    go.drugbank.com/bio_entities/BE0009087
    TargetHumans

    Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament networ...

    Polypeptides: Keratin, type II cytoskeletal 5Synonyms: CK-5, Keratin-5
  4. Target

    Protein arginine N-methyltransferase 5

    go.drugbank.com/bio_entities/BE0011121
    TargetHumans

    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, P...

    Polypeptides: Protein arginine N-methyltransferase 5
  5. Target

    Inositol polyphosphate 5-phosphatase OCRL

    go.drugbank.com/bio_entities/BE0013933
    EnzymeHumans

    Also, is able to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:15474001, PubMed:40969890, PubMed:7761412). … Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic

    Polypeptides: Inositol polyphosphate 5-phosphatase OCRLSynonyms: Inositol polyphosphate 5-phosphatase OCRL-1, Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
  6. Target

    Splicing factor 3B subunit 5

    go.drugbank.com/bio_entities/BE0018936
    TargetHumans

    Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2...

    Polypeptides: Splicing factor 3B subunit 5Synonyms: Pre-mRNA-splicing factor SF3b 10 kDa subunit
  7. Drug

    Levamlodipine

    go.drugbank.com/drugs/DB09237
    ApprovedInvestigational

    [A188940] Levamlodipine was granted FDA approval on 19 December 2019.[L10833] … [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.

    Mixtures: VOLTRAMOS 5 MG/160 MG FILM KAPLI TABLET, 28 ADET, ALENCAL VALS 5/320 MG TABLETAS RECUBIERTASCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates
  8. Drug

    Epoprostenol

    go.drugbank.com/drugs/DB01240
    ApprovedInvestigational

    A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue.

    Categories: Prostaglandins ISynonyms: (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
  9. Drug

    Ioxitalamic acid

    go.drugbank.com/drugs/DB13444
    ApprovedWithdrawn

    [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg.

    Mixtures: TELEBRIX 35 FLAKON, 100 ML, TELEBRIX 35 FLAKON, 100 MLCategories: X-Ray Contrast Media, Iodinated, Compounds used in a research, industrial, or household setting
  10. Drug

    Mefloquine

    go.drugbank.com/drugs/DB00358
    Approved

    Individuals at the highest risk for malaria are those in disease naïve populations, children under age 5, refugees in Central and Eastern Africa, nonimmune civilian and military travelers, pregnant women … The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019.

    Mixtures: อาร์ทีซูเนทและเมฟลอควินไฮโดรคลอไรด์ 100/220 มก., อาร์ทีซูเนทและเมฟลอควินไฮโดรคลอไรด์ 25/55 มก.Categories: P-glycoprotein inhibitors, P-glycoprotein substrates