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Vutrisiran
go.drugbank.com/drugs/DB16699ApprovedInvestigational[A249010] More than 130 TTR mutations have been identified so far,[A249015] but the most common one is the replacement of valine with methionine at position 30 (Val30Met). … [A249025,L42065] This delivery platform gives vutrisiran high potency and metabolic stability, and allows for subcutaneous injections to take place once every three months.
Cobalt
go.drugbank.com/drugs/DB14574ApprovedWithdrawnExcept for radioactive forms of cobalt and cobalamin, the FDA withdrew its approval for the use of drug products containing cobalt salts.[L43942] … Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
Sparteine
go.drugbank.com/drugs/DB06727ApprovedWithdrawnSparteine is a plant alkaloid derived from _Cytisus scoparius_ and _Lupinus mutabilis_ which may chelate calcium and magnesium. … Sparteine is not currently FDA-approved for human use, and its salt, sparteine sulfate, is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsPF-06835919
go.drugbank.com/drugs/DB19163InvestigationalPF-06835919 is under investigation in clinical trial NCT05463575 (Ketohexokinase Inhibition in NAFLD).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesPomalidomide
go.drugbank.com/drugs/DB08910ApprovedInvestigationalPomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesMethylmethionine chloride
go.drugbank.com/drugs/DB13250ExperimentalMethylmethionine chloride may be useful in helping the healing of gastric ulcers. In Japan, it is used as an over the counter product for gastrointestinal health support.
Categories: Drugs for Acid Related Disorders, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Padeliporfin
go.drugbank.com/drugs/DB15575ApprovedInvestigationalPadeliporfin is a water-soluble chlorophyll derivative and cytotoxic photosensitizer used for vascular-targeted photodynamic therapy for malignancies. … [A244559] Vascular-targeted photodynamic therapy (VTP), or vascular targeted photochemotherapy, is a focal treatment for localized prostate cancer.
Prochlorperazine
go.drugbank.com/drugs/DB00433ApprovedInvestigationalVet approvedProchlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAceclofenac
go.drugbank.com/drugs/DB06736ApprovedAceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. … In 1991, aceclofenac was developed as an analog of a commonly prescribed NSAID, [DB00586], via chemical modification in effort to improve the gastrointestinal tolerability of the drug.
Mixtures: ZERODOL PCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesFlutemetamol (18F)
go.drugbank.com/drugs/DB09151ApprovedInvestigationalFlutemetamol (18F), an analogue of [(11)C]PIB,[A18519] is a radioactive diagnostic drug used for Positron Emission Tomography (PET) imaging of the brain to estimate β amyloid neuritic plaque density. … It is used to evaluate Alzheimer's disease (AD) or other causes of cognitive decline as an Aβ-specific positron emission tomography (PET) ligand.[L35029]