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PF-06835919

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Data Packages
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Identification

Generic Name
PF-06835919
DrugBank Accession Number
DB19163
Background

PF-06835919 is under investigation in clinical trial NCT05463575 (Ketohexokinase Inhibition in NAFLD).

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 356.349
Monoisotopic: 356.146010357
Chemical Formula
C16H19F3N4O2
Synonyms
  • (1α,5α,6α)-3-[2-[(2S)-2-Methyl-1-azetidinyl]-6-(trifluoromethyl)-4-pyrimidinyl]-3-azabicyclo[3.1.0]hexane-6-acetic acid
  • 2-((1S,5R)-3-(2-((2S)-2-METHYLAZETIDIN-1-YL)-6-(TRIFLUOROMETHYL)PYRIMIDIN-4-YL)-3-AZABICYCLO(3.1.0)HEXAN-6-YL)ACETIC ACID
External IDs
  • PF-06835919
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
EC2P9H3A8S
CAS number
2102501-84-6
InChI Key
MDUYWDNWFXSMJJ-XWLWVQCSSA-N
InChI
InChI=1S/C16H19F3N4O2/c1-8-2-3-23(8)15-20-12(16(17,18)19)5-13(21-15)22-6-10-9(4-14(24)25)11(10)7-22/h5,8-11H,2-4,6-7H2,1H3,(H,24,25)/t8-,10+,11+/m1/s1
IUPAC Name
SMILES
[H][C@@]12CN(C[C@]1([H])[C@H]2CC(O)=O)C1=CC(=NC(=N1)N1CC[C@@H]1C)C(F)(F)F

References

General References
Not Available
ChemSpider
71117478
BindingDB
319585
ChEMBL
CHEMBL4549658
PDBe Ligand
S6D
PDB Entries
6w0z

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2CompletedBasic ScienceFatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD1somestatusstop reasonjust information to hide
2CompletedBasic ScienceSteatohepatitis, Nonalcoholic1somestatusstop reasonjust information to hide
2CompletedTreatment(NAFLD)1somestatusstop reasonjust information to hide
1CompletedBasic ScienceHealthy Volunteers (HV)2somestatusstop reasonjust information to hide
1CompletedBasic ScienceHealthy Volunteers (HV) / Hepatic Impairment (HI)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at July 05, 2024 18:41 / Updated at July 06, 2024 06:45