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Displaying results 3661 - 3670 of 3888 in total
  1. Target

    Cyclin-dependent kinase 8

    go.drugbank.com/bio_entities/BE0002224
    TargetHumans

    Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression (PubMed:10993082). … Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.

    Synonyms: Mediator complex subunit CDK8
  2. Target

    Proteasome subunit alpha type-4

    go.drugbank.com/bio_entities/BE0003913
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex subunit C9
  3. Target

    Atypical kinase COQ8A, mitochondrial

    go.drugbank.com/bio_entities/BE0009381
    TargetHumans

    Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed:25540914, PubMed:27499294, PubM...

    Synonyms: Chaperone activity of bc1 complex-like
  4. Drug

    Promestriene

    go.drugbank.com/drugs/DB12487
    Investigational

    Promestriene (3-propyl ethyl, 17B-methyl estradiol) has been used in trials studying the prevention of Hypospadias. It is a synthetic estrogen analog, which is used in topical estrogen therapy. Promestriene’s potential for treating vagin...

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  5. Drug

    Pibrentasvir

    go.drugbank.com/drugs/DB13878
    ApprovedInvestigational

    This fixed-dose combination therapy was FDA-approved in August 2017 to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis, including

  6. Drug

    Zastaprazan

    go.drugbank.com/drugs/DB21524
    Investigational

    The usage of the INN stem '-prazan' in the name indicates that Zastaprazan is a proton pump inhibitor, not dependent on acid activation.

  7. Drug

    Amsilarotene

    go.drugbank.com/drugs/DB21085
    Investigational

    The usage of the INN stem '-arotene' in the name indicates that Amsilarotene is a arotinoid derivative.

  8. Drug

    Prusogliptin

    go.drugbank.com/drugs/DB20606
    Investigational

    The usage of the INN stem '-gliptin' in the name indicates that Prusogliptin is a dipeptidyl aminopeptidase-IV inhibitor.

  9. Drug

    Guretolimod

    go.drugbank.com/drugs/DB21487
    Investigational

    The usage of the INN stem '-tolimod' in the name indicates that Guretolimod is a toll-like receptor (TLR) agonist.

  10. Drug

    Ocedurenone

    go.drugbank.com/drugs/DB21519
    Investigational

    The usage of the INN stem '-renone' in the name indicates that Ocedurenone is a mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonist.