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Displaying results 361 - 370 of 10000 in total
  1. Drug

    Streptokinase

    go.drugbank.com/drugs/DB00086
    ApprovedInvestigationalWithdrawn

    Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.

    Products: KABIKINASE AMPOLLAS DE 750.000 UI POLVO PµRA INYECCION, Streptokinase Karma 1 500 000 IU Powder for Solution for Infusion
  2. Drug

    Betamethasone

    go.drugbank.com/drugs/DB00443
    ApprovedInvestigationalVet approved

    [A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. … Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties.

    Mixtures: DIFAZIN MAX ®., PHI KANG YANGCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  3. Drug

    Nicotine

    go.drugbank.com/drugs/DB00184
    ApprovedInvestigational

    Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of it...

    Synonyms: (S)-3-(1-methylpyrrolidin-2-yl)pyridine, (S)-3-(N-methylpyrrolidin-2-yl)pyridineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers
  4. Drug

    Darifenacin

    go.drugbank.com/drugs/DB00496
    ApprovedInvestigational

    Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions.

    Synonyms: (S)-1-(2-(2,3-dihydro-5-benzofuranyl)ethyl)-α,α-diphenyl-3-pyrrolidineacetamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  5. Drug

    Pemtumomab

    go.drugbank.com/drugs/DB18563
    Experimental

    Pemtumomab is a murine monoclonal antibody radiolabeled with Yttrium-90. It targets the mucin 1 (MUC1) protein.

    Synonyms: Murine MAb to polymorphic epithelial mucin, human milk fat globule 1
  6. Drug

    Pantoprazole

    go.drugbank.com/drugs/DB00213
    ApprovedInvestigational

    [A177577, A177580] Pantoprazole doses should be slowly lowered, or tapered, before discontinuing as rapid discontinuation of PPIs such as pantoprazole may cause a rebound effect and a short term increase … increased risk of developing hypomagnesemia and hypocalcemia which may contribute to osteoporosis and bone fractures later in life.

    Mixtures: OCAM® DUO.Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
  7. Drug

    Mavacamten

    go.drugbank.com/drugs/DB14921
    ApprovedInvestigational

    Mavacamten is a myosin inhibitor indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM).

    Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesSynonyms: 6-(((1S)-1-Phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 tetrahydropyrimidine-2,4-dione
  8. Drug

    Quinapril

    go.drugbank.com/drugs/DB00881
    ApprovedInvestigational

    [L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423] … [L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.

    Mixtures: QUINAPRIL E IDROCLOROTIAZIDE ACTAVIS, QUINAPRIL E IDROCLOROTIAZIDE MYLAN GENERICSCategories: Heterocyclic Compounds, 2-Ring
  9. Drug

    Clomipramine

    go.drugbank.com/drugs/DB01242
    ApprovedInvestigationalVet approved

    They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. … Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder).

    Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexSynonyms: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine, 3-(3-chloro-5H-dibenzo[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine
  10. Drug

    Terlipressin

    go.drugbank.com/drugs/DB02638
    ApprovedInvestigational

    Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor.[A2601] It is a prodrug of [lypressin], or lysine vasopressin. … Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor.

    Products: TERLIPRESSINA DR. REDDY'S, HAEMOPRESSIN® 1 MG