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Displaying results 3691 - 3700 of 10000 in total

Drug
Topiroxostat
go.drugbank.com/drugs/DB01685
Investigational
Approved for therapeutic use in Japan since 2013, topiroxostat is marketed under the name Topiloric and Uriadec and is orally administered twice daily. … Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
Drug
Cyclacillin
go.drugbank.com/drugs/DB01000
Approved
A cyclohexylamido analog of penicillanic acid.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
Drug
AB-201
go.drugbank.com/drugs/DB18629
Investigational
AB-201 is a CAR-NK cell therapy targeted against HER2.[L48340] It is under investigation for the treatment of HER2-positive cancers, including breast and gastric carcinomas.
Synonyms: Ex vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a HER2-directed CAR and secrete IL-15
Drug
Cilomilast
go.drugbank.com/drugs/DB03849
Investigational
Following four clinical trials, the drug proved to be effective in treating COPD, however it has never been marketed due to a poor side effect profile. … Cilomilast (Ariflo, SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD).
Drug
Bepridil
go.drugbank.com/drugs/DB01244
ApprovedWithdrawn
It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes). … A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects.
Categories: Non-Selective Calcium Channel BlockersSynonyms: .-((2-METHYLPROPOXY)METHYL)-N-PHENYL-N-(PHENYLMETHYL)-, 1-(2-(N-BENZYLANILINO)-1-(ISOBUTOXYMETHYL)ETHYL)-PYRROLIDINE
Drug
VIT-100
go.drugbank.com/drugs/DB05865
Experimental
In preclinical studies, companyl has shown that VIT-100 inhibits the growth of cells taken from multiple keloid biopsies as compared to the same keloidal cells treated with a control. … It is believed that similar effects would be seen in cells isolated from hypertrophic scars.
Drug
CZEN 002
go.drugbank.com/drugs/DB05479
Experimental
(6-9) that is important for binding to the known melanocortin receptors. … A second focus was on the sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial activity.
Drug
Camostat
go.drugbank.com/drugs/DB13729
Investigational
Camostat mesylate, or FOY-305, is a synthetic serine protease inhibitor. … [A193842,A193848] It was first described in the literature in 1981, as part of research on the inhibition of skin tumors in mice.
Drug
Enoxacin
go.drugbank.com/drugs/DB00467
Approved
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
Drug
Tiagabine
go.drugbank.com/drugs/DB00906
Approved
Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. … Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.