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Displaying results 3731 - 3740 of 8698 in total
  1. Drug

    Telotristat ethyl

    go.drugbank.com/drugs/DB12095
    Approved

    [L43367] Overexposure to serotonin can cause severe diarrhea, one of the main clinical symptoms of carcinoid syndrome. … [A252947] Neuroendocrine tumors (NET) arising from these cells can therefore secrete chemical mediators into the bloodstream to cause side effects in distant sites, a phenomenon called carcinoid syndrome

    Categories: Cytochrome P-450 CYP2B6 Inducers, P-glycoprotein inhibitors
  2. Drug

    105AD7

    go.drugbank.com/drugs/DB05113
    Investigational

    metastatic colorectal cancer patients. 105AD7 may be a suitable vaccine for treatment of this disease. … 105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed by many solid tumours including osteosarcoma. 105AD7 induced antitumour inflammatory responses in

  3. Drug

    Cefmenoxime

    go.drugbank.com/drugs/DB00267
    Approved

    Cefmenoxime is a novel broad-spectrum and third-generation cephalosporin antibiotic that is typically used in the treatment of female gynecologic and obstetric infections. It is reported to exhibit high activity against a wide variety of...

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
  4. Drug

    Tetrabenazine

    go.drugbank.com/drugs/DB04844
    Approved

    A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  5. Drug

    Phenylethyl resorcinol

    go.drugbank.com/drugs/DB14120
    ApprovedWithdrawn

    A tyrosinase inhibitor with skin-lightening activity.

    Mixtures: I-max Lightening 5
  6. Drug

    Nelfinavir

    go.drugbank.com/drugs/DB00220
    ApprovedInvestigational

    Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the...

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
  7. Drug

    N-(2-Aminoethyl)-1-aziridineethanamine

    go.drugbank.com/drugs/DB15643
    Experimental

    First described in the literature in 2004, N-(2-Aminoethyl)-1-aziridineethanamine is an experimental angiotensin converting enzyme 2 inhibitor investigated for its use in treating cardiovascular disease

  8. Drug

    PF-03654764

    go.drugbank.com/drugs/DB12360
    Investigational

    PF-03654764 has been used in trials studying the basic science and treatment of Allergic Rhinitis.

  9. Drug

    Tepotinib

    go.drugbank.com/drugs/DB15133
    ApprovedInvestigational

    [L31443,L31473] It is the first oral MET-targeted tyrosine kinase inhibitor to allow for once-daily dosing,[L31473] an advantage that may aid in easing the pill burden often associated with chemotherapeutic … In February 2022, tepotinib was approved for use in Europe.[L42200]

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  10. Drug

    Neltenexine

    go.drugbank.com/drugs/DB13239
    Investigational

    Neltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.