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Displaying results 3741 - 3750 of 10000 in total
  1. Drug

    PX-12

    go.drugbank.com/drugs/DB05448
    Investigational

    PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits … Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced

    Synonyms: 1-Methylpropyl-2-imidazolyl disulfideCategories: Heterocyclic Compounds, 1-Ring
  2. Drug

    PXS-4728A free base

    go.drugbank.com/drugs/DB19177
    Investigational

    PXS-4728A free base is under investigation in clinical trial NCT05904717 (Effect of PXS-4728A on Microglia Activation in Participants With Isolated Rapid Eye Movement Sleep Behaviour Disorder).

    Synonyms: Benzamide, 4-(((2e)-2-(aminomethyl)-3-fluoro-2-propen-1-yl)oxy)-n-(1,1-dimethylethyl)-
  3. Drug

    N-acetyl-D-glucosamine-6-phosphate

    go.drugbank.com/drugs/DB03951
    Experimental

    Synonyms: 2-acetamido-2-deoxy-6-O-phosphono-D-glucopyranose, N-acetyl-D-glucosamine-6-phosphate
  4. Drug

    Triapine

    go.drugbank.com/drugs/DB11940
    Investigational

    Triapine has been used in trials studying the treatment of Leukemia, Lung Cancer, Kidney Cancer, Prostate Cancer, and Pancreatic Cancer, among others.

    Synonyms: 3-Aminopyridine-2-carboxaldehyde thiosemicarbazoneCategories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Ocrylate

    go.drugbank.com/drugs/DB15086
    Experimental

    Ocrylate is under investigation in clinical trial NCT01918059 (Cosmetic Outcome Study of Lid Laceration Repair With Suture Versus Tissue Adhesive).

    Synonyms: OCTYL-2-CYANOACRYLATECategories: Compounds used in a research, industrial, or household setting
  6. Drug

    VXM01

    go.drugbank.com/drugs/DB17420
    Investigational

    Synonyms: VEGFR-2 DNA vaccine VXM01
  7. Drug

    Ethanolamine

    go.drugbank.com/drugs/DB03994
    Investigational

    A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. … It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.

    Synonyms: 2-Aminoethanol
  8. Drug

    Polydatin

    go.drugbank.com/drugs/DB11263
    Approved

    Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. … It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis [A27229].

    Synonyms: 3,4',5-trihydroxystilbene-3-β-d-glucoside, Polydatin (E)-isomer
  9. Drug

    Tiazofurine

    go.drugbank.com/drugs/DB13243
    Experimental

    Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase [A174991].

    Synonyms: 2-(β-D-ribofuranosyl)-4-thiazolecarboxamide, 2-β-D-ribofuranosyl-4-thiazolecarboxamide
  10. Drug

    4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide

    go.drugbank.com/drugs/DB01888
    Experimental

    Synonyms: 4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide