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Sulfamethizole
go.drugbank.com/drugs/DB00576ApprovedVet approvedA sulfathiazole antibacterial agent.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: S- URISTIX 500 MG CAPSULAS, S*ORIPOL FORTE - SULFAMETIZOL 500 MG CAPSULASDelamanid
go.drugbank.com/drugs/DB11637ApprovedInvestigationalSpontaneous resistance to delamanid was observed during treatment, where mutation in one of the 5 F420 coenzymes responsible for bioactivation of delamanid contributes to this effect [L1407]. … It is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in a combination regimen.
Synonyms: (R)-2-methyl-6-nitro-2-{4-[4-(4-trifluoromethoxyphenoxy)piperidin-1-yl]phenoxymethyl}-2,3-dihydroimidazo[2,1-b]oxazole, (2R)-2-methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo(2,1-B)(1,3)oxazoleCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesApalutamide
go.drugbank.com/drugs/DB11901ApprovedInvestigationalApproximately 10 to 20 % of prostate cancer cases are castration-resistant, and up to 16% of these patients show no evidence of cancer metastasis at the time of castration-resistant diagnosis [L1295]. … In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846].
Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingProducts: ERLEADA ®TABLETAS RECUBIERTAS 60 MGFlunitrazepam
go.drugbank.com/drugs/DB01544ApprovedIllicitSome reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. … Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia.
Categories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedativesProducts: Rohypnol 1 mg - Filmtabletten, ROHYPNOL ROCHE TABLETAS 1 MGTolbutamide
go.drugbank.com/drugs/DB01124ApprovedTolbutamide and its metabolites are excreted in urine (75-85%) and feces. … It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin
Synonyms: 1-Butyl-3-tosylurea, 1-Butyl-3-(p-tolylsulfonyl)ureaCategories: Alimentary Tract and Metabolism, Genito Urinary System and Sex HormonesAcipimox
go.drugbank.com/drugs/DB09055ApprovedInvestigationalAdverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. … Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL.
Categories: Heterocyclic Compounds, 1-Ring, Nicotinic Acid and DerivativesProducts: OLBETAM CAPSULE 250 mgHyaluronidase
go.drugbank.com/drugs/DB14740ApprovedInvestigational[A199047] Hyaluronidase was first used in prescription products in the United States on 5 May 2004.[L13338] … [A199026] Hyaluronidase has been used in surgical settings for at least the past 60 years to improve the diffusion of local anesthetics.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansProducts: Wydase Injection Liq 150 Units/ml, HYLASE® DESSAU 150 IUCardiolipin Biosynthesis CL(10:0/10:0/10:0/18:2(9Z,11Z))
smpdb.ca/view/SMP0175283MetabolicCardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial...
Regorafenib
go.drugbank.com/drugs/DB08896ApprovedInvestigationalIt is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012.
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsProducts: STIVARGA 40 MG TABLETA RECUBIERTA, STIVARGA 40 MG FILM KAPLI TABLET ,84 ADETTelithromycin
go.drugbank.com/drugs/DB00976ApprovedBinding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. … Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides.
Categories: Erythromycin and similars, Macrolides, Lincosamides and StreptograminsProducts: KETEK ® 400 MG