Sulfamethizole

DB00576ApprovedVet approvedSmall moleculeSulfonamide Antibacterial

Sulfamethizole is a sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections. A sulfathiazole antibacterial agent.

Mechanism: Sulfamethizole is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Curator reviewed
Primary indication: For the treatment of urinary tract infectionCurator reviewed · 9 structured indications
Formula / weight: C₉H₁₀N₄O₂S₂ · 270.331 g/mol (avg)
First approval: United States, 2005
Also known as: Sulfamethylthiadiazole
Brand names: Urobiotic

Resolves to

Compound

UNII25W8454H16CAS144-82-1ChEMBLCHEMBL1191ChEBI9331PubChem5328KEGGD00870

Clinical / RWD

RxNorm10179ATCB05CA04ATCD06BA04ATCG01AE10PharmGKBPA164781307

Structure

InChIKeyVACCAVUAMIDAGB-UHFFFAOYSA-NSMILESCC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1

Targets

P0AC13folP

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

761Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

9Structured indicationsCondition, population, route and combination as fields, not prose

9Marketed productsAcross 5 countries and 8 labellers

5ATC codesIncluding every combination product, plus 31 drug categories

13+ReferencesStructured and connected to the statements they support

Which drugs share a target with Sulfamethizole, and which of those have an active Phase 3 trial?

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