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Donidalorsen
go.drugbank.com/drugs/DB18751ApprovedInvestigational[L53788] Donidalorsen was approved by the FDA in August 2025 for prophylactic use to prevent HAE attacks.[L53783,L53788] It is the first RNA-targeted therapy approved for HAE.[L53783] … Hereditary angioedema (HAE) is a rare genetic disease characterized by recurrent episodes of severe swelling induced by excessive production of bradykinin.
Prademagene zamikeracel
go.drugbank.com/drugs/DB17895ApprovedInvestigational[L53008] COL7A1 encodes type VII collagen (C7), which is a major component of anchoring fibrils (AF) that are critical for dermal-epidermal cohesion. … Prademagene zamikeracel is a sheet-based gene therapy comprising autologous cells isolated from skin punch biopsies of patients with mutations in the collagen type VII alpha 1 chain (COL7A1) gene.
Categories: Complex MixturesCefotiam
go.drugbank.com/drugs/DB00229ApprovedOne of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseOrnidazole
go.drugbank.com/drugs/DB13026InvestigationalOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
Categories: Genito Urinary System and Sex Hormones, Antibacterials for Systemic UseAldosterone
go.drugbank.com/drugs/DB04630InvestigationalA hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Categories: Sex Hormones and Insulins, Corticosteroids for Systemic UseFlorbetapir F-18
go.drugbank.com/drugs/DB09149ApprovedInvestigationalMarketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment … The radionucleide fluorine-18 was chosen as it has a half life of 110 minutes allowing it to accumulate sufficiently in the brain before undergoing positon emission decay.
MMDA
go.drugbank.com/drugs/DB01442ExperimentalIllicitThe effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals. … MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen.
OTL-102
go.drugbank.com/drugs/DB18642ExperimentalIt is being investigated for the treatment of X-linked chronic granulomatous disease. … OTL-102 consists of autologous CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene.
Synonyms: Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox geneApalutamide
go.drugbank.com/drugs/DB11901ApprovedInvestigationalIt is available as oral tablets. Apalutamide is the first FDA-approved treatment for non-metastatic, castration-resistant prostate cancer [L1295]. … Apalutamide was approved in February 2018 by the FDA as Erleada for the treatment of patients with non-metastatic prostate cancer that is resistant to treatment with hormone therapy (castration-resistant
Xanomeline
go.drugbank.com/drugs/DB15357ApprovedInvestigationalSchizophrenia is a complex disease involving a number of different neurotransmitters, including serotonin, dopamine, and acetylcholine. … receptors as opposed to dopamine receptors.