Aldosterone

DB04630InvestigationalSmall molecule

A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.

Mechanism: Pharmacologically active on Mineralocorticoid receptor
Curator reviewed
Formula / weight: C₂₁H₂₈O₅ · 360.444 g/mol (avg)

Resolves to

Compound

UNII4964P6T9RBCAS52-39-1ChEMBLCHEMBL273453ChEBI27584PubChem5839KEGGC01780

Clinical / RWD

RxNorm1312358ATCH02AA01PharmGKBPA164924487

Structure

InChIKeyPQSUYGKTWSAVDQ-ZVIOFETBSA-NSMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C=O)C(=O)CO

Targets

P08235NR3C2Q13621SLC12A1P04150NR3C1

Transporters

P08183ABCB1O76082SLC22A5P46721SLCO1A2

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3TransportersSubstrate / inhibitor direction, not just membership

Listed above

1,059Drug interactionsStructured to mechanism, not free text

26Clinical trialsPhase, status and sponsor resolved per trial

1ATC codeIncluding every combination product, plus 21 drug categories

22+ReferencesStructured and connected to the statements they support

Which drugs share a target with Aldosterone, and which of those have an active Phase 3 trial?

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