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Amuvatinib
go.drugbank.com/drugs/DB12742InvestigationalAmuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer cells.
Synonyms: 1-Piperazinecarbothioamide, N-(1,3-benzodioxol-5-ylmethyl)-4-benzofuro(3,2-d)pyrimidin-4-yl-, 4-[1]Benzofuro[3,2-D]Pyrimidin-4-Yl-N-(1,3-Benzodioxol-5-Ylmethyl)Piperazine-1-CarbothioamideExagamglogene autotemcel
go.drugbank.com/drugs/DB15572ApprovedInvestigationalSickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe … [L10139] Following engraftment, it causes an increase in the production of HbF and a subsequent decrease in HbS.
Synonyms: from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediated gene editing consisting of aFremanezumab
go.drugbank.com/drugs/DB14041ApprovedInvestigational[L11749] It was developed by Teva Pharmaceuticals USA and approved by the FDA in September 2018. … Fremanezumab is a humanized monoclonal antibody targeted against human calcitonin gene-related peptide (CGRP) for the prevention of migraine headaches.
Cobalt
go.drugbank.com/drugs/DB14574ApprovedWithdrawnA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. … Except for radioactive forms of cobalt and cobalamin, the FDA withdrew its approval for the use of drug products containing cobalt salts.[L43942]
Azathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigationalAzathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic … [L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Products: AZATHIOPRIN 1A PHARMA 25MG, AZATHIOPRIN 1A PHARMA 50MGTiludronic acid
go.drugbank.com/drugs/DB01133ApprovedVet approvedWithdrawn[A1923] Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone.[A202235] Tiludronic acid was granted FDA approval on 7 March 1997.[L4763] … [A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.
Categories: Phospholipases A, antagonists & inhibitorsMorphine
go.drugbank.com/drugs/DB00295ApprovedInvestigationalMorphine was granted FDA approval in 1941.[L12114] … [A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.
Products: MORPH 1A PHARMA 20MG, MORPH 1A PHARMA 45MGNizubaglustat
go.drugbank.com/drugs/DB21603InvestigationalNizubaglustat has a monoisotopic molecular weight of 433.23 Da. … Nizubaglustat is a small molecule drug. The usage of the INN stem '-glustat' in the name indicates that Nizubaglustat is a ceramide glucosyltransferase inhibitor.
Nevadistinel
go.drugbank.com/drugs/DB21632InvestigationalNevadistinel has a monoisotopic molecular weight of 274.13 Da. … Nevadistinel is a small molecule drug. The usage of the INN stem '-stinel' in the name indicates that Nevadistinel is a N-methyl-D-aspartate (NMDA) receptor co-agonist.
Vicadrostat
go.drugbank.com/drugs/DB21693InvestigationalVicadrostat has a monoisotopic molecular weight of 317.06 Da. … Vicadrostat is a small molecule drug. The usage of the INN stem '-drostat' in the name indicates that Vicadrostat is a inhibitor of the synthesis of aldosterone and cortisol.