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Displaying results 3941 - 3950 of 7284 in total
  1. Drug

    Upacicalcet

    go.drugbank.com/drugs/DB20023
    Investigational

    Upacicalcet has a monoisotopic molecular weight of 351.03 Da. … Upacicalcet is a small molecule drug. The usage of the INN stem '-calcet/-calcet-' in the name indicates that Upacicalcet is a calcium-sensing receptor (CaSR) agonist.

  2. Drug

    Atuveciclib

    go.drugbank.com/drugs/DB20084
    Investigational

    Atuveciclib has a monoisotopic molecular weight of 387.12 Da. … Atuveciclib is a small molecule drug. The usage of the INN stem '-ciclib' in the name indicates that Atuveciclib is a cyclin dependant kinase inhibitor.

  3. Drug

    Lapretolimod

    go.drugbank.com/drugs/DB20120
    Investigational

    Lapretolimod has a monoisotopic molecular weight of 1745.28 Da. … Lapretolimod is a small molecule drug. The usage of the INN stem '-tolimod' in the name indicates that Lapretolimod is a toll-like receptor (TLR) agonist.

    Synonyms: Glucopyranosyl lipid a
  4. Drug

    Bavtavirine

    go.drugbank.com/drugs/DB21527
    Investigational

    Bavtavirine has a monoisotopic molecular weight of 416.17 Da. … Bavtavirine is a small molecule drug. The usage of the INN stem '-virine' in the name indicates that Bavtavirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).

  5. Drug

    Cenacitinib

    go.drugbank.com/drugs/DB21735
    Investigational

    Cenacitinib has a monoisotopic molecular weight of 431.15 Da. … Cenacitinib is a small molecule drug. The usage of the INN stem '-citinib' in the name indicates that Cenacitinib is a Janus kinase inhibitor.

  6. Target

    Succinate dehydrogenase

    go.drugbank.com/bio_entities/BE0010253
    EnzymeTargetHumans

    Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed … Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to

    Synonyms: Flavoprotein subunit of complex II, Iron-sulfur subunit of complex II
  7. Drug

    Trilaciclib

    go.drugbank.com/drugs/DB15442
    ApprovedInvestigational

    [A229313] Trilaciclib was granted FDA approval on 12 February 2021.[L31823] … Trilaciclib, or G1T28, is a CDK4 and CDK6 inhibitor, indicated to reduce the incidence of chemotherapy induced myelosuppression in patients before topotecan-containing or platinum and etoposide-containing

  8. Drug

    Fleroxacin

    go.drugbank.com/drugs/DB04576
    Experimental

    Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase. Fleroxacin is not an inhibitor of CYP1A2.[A39048]

  9. Drug

    Relebactam

    go.drugbank.com/drugs/DB12377
    ApprovedInvestigational

    [A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge. … [label] It is considered to be a last-line treatment option and gained FDA approval as part of the combination product RecarbrioⓇ in July 2019.[L7568]

  10. Drug

    Tenecteplase

    go.drugbank.com/drugs/DB00031
    ApprovedInvestigational

    Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). … It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids