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Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
go.drugbank.com/bio_entities/BE0003888TargetHumansContributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677) … Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity).
Polypeptides: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Synonyms: Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoformVoltage gated L-type calcium channel
go.drugbank.com/bio_entities/BE0009739TargetHumansIncreases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity) … Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Polypeptides: Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent L-type calcium channel subunit alpha-1DSynonyms: Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-gated calcium channel subunit alpha Cav1.3Tumor-associated calcium signal transducer 2
go.drugbank.com/bio_entities/BE0009918TargetHumansMay function as a growth factor receptor
Polypeptides: Tumor-associated calcium signal transducer 2Synonyms: Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
go.drugbank.com/bio_entities/BE0003477TargetTransporterHumansAlso modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). … This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920).
Polypeptides: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Synonyms: Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoformVoltage-dependent L-type calcium channel
go.drugbank.com/bio_entities/BE0008715TargetTransporterHumansThe isoform alpha-1A gives rise to P and/or Q-type calcium currents. … Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity)
Polypeptides: Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent L-type calcium channel subunit alpha-1DSynonyms: Brain calcium channel I, Voltage-gated calcium channel subunit alpha Cav1.2Voltage-dependent T-type calcium channel
go.drugbank.com/bio_entities/BE0008716TargetTransporterHumansThis channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. … Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone
Polypeptides: Voltage-dependent T-type calcium channel subunit alpha-1G, Voltage-dependent T-type calcium channel subunit alpha-1HSynonyms: Voltage-gated calcium channel subunit alpha Cav3.1, Voltage-gated calcium channel subunit alpha Cav3.2Voltage-dependent R-type calcium channel
go.drugbank.com/bio_entities/BE0008718TransporterTargetHumansThe isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. … They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Polypeptides: Voltage-dependent R-type calcium channel subunit alpha-1ESynonyms: Brain calcium channel II, Voltage-gated calcium channel subunit alpha Cav2.3Voltage-dependent N-type calcium channel
go.drugbank.com/bio_entities/BE0009351TargetHumansThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. … The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990).
Polypeptides: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2/delta-2Synonyms: Brain calcium channel III, Voltage-gated calcium channel subunit alpha-2/delta-1Calcium-transporting ATPase type 2C member 1
go.drugbank.com/bio_entities/BE0000218TargetHumansMay also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401) … Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity).
Polypeptides: Calcium-transporting ATPase type 2C member 1Calcium/calmodulin-dependent protein kinase type 1G
go.drugbank.com/bio_entities/BE0004147TargetHumansCalcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity)
Polypeptides: Calcium/calmodulin-dependent protein kinase type 1G