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Satralizumab
go.drugbank.com/drugs/DB15762ApprovedInvestigationalsatralizumab formulation developed by Chugai Pharmaceutical and Roche,[L15536] is uniquely formulated with "recycling antibody technology" whereby the association of satralizumab to IL-6 receptors occurs in a pH-dependent … manner[A218551] - this allows satralizumab to bind an IL-6 receptor until it reaches an endosome, after which the drug may dissociate from the receptor and move back into the plasma to act again.
Categories: Interleukin-6 Receptor AntagonistSynonyms: Humanised anti-IL-6 receptor monoclonal antibodyArbutin
go.drugbank.com/drugs/DB11217ApprovedIt is found in foods, over-the-counter drugs, and herbal dietary supplements [F43].
Mixtures: The Prestige BB SPF25 PA 2Plus, Absolute Total BB SPF37 PA 3PlusSynonyms: p-hydroxyphenyl β-D-glucoside, p-hydroxyphenyl β-D-glucopyranosideNipocalimab
go.drugbank.com/drugs/DB16257ApprovedInvestigationalNipocalimab-aahu is a neonatal Fc receptor (FcRn) blocker used to treat certain antibody-mediated autoimmune diseases.
Categories: Neonatal Fc Receptor BlockerSynonyms: immunoglobulin G1-lambda, anti-[Homo sapiens FCGRT (Fc fragment of IgG receptor and transporter, neonatal Fc receptor, FcRn, transmembrane alpha chain of the neonatal receptor)], Homo sapiens monoclonal, Immunoglobulin g1, anti-(human neonatal fc receptor) (human monoclonal m281 .gamma.-1 chain), disulfide with human monoclonal m281 .lambda.-chain, dimerAluminum chloride
go.drugbank.com/drugs/DB11081ApprovedInvestigationalIt may also be found in over-the-counter as an antiperspirant or prescription products as an antihemorrhagic agent.
Products: Duradry PM, Clinical Strength MiracleDry Antiperspirant Deodorant PMTagraxofusp
go.drugbank.com/drugs/DB14731ApprovedInvestigationalTagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in Escherichia co...
Synonyms: Diphtheria toxin-il-3 fusion protein targeting IL-3 receptorDolutegravir
go.drugbank.com/drugs/DB08930ApprovedInvestigationalDolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent to...
Mixtures: Triumeq PDCategories: P-glycoprotein substratesInsulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalDue to the added crystals, NPH insulin is typically cloudy when compared to other forms of insulin and has a neutral pH. … Unfortunately, limited uptake by physicians and patients, poor sales, bulky packaging, and concerns over the possible impact on lung cancer development resulted in Exubera products being withdrawn from
Mixtures: HUMINSULIN PROFIL III F PE, HUMINSULIN PROFIL III F PECategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersNifedipine
go.drugbank.com/drugs/DB01115ApprovedInvestigationalNifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972....
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: Adalat Pa 20, Apo-nifed PaMethyl aminolevulinate
go.drugbank.com/drugs/DB00992ApprovedInvestigationalMethyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.
Products: KRX Aesthetics PD-13 TherapyAmsacrine
go.drugbank.com/drugs/DB00276ApprovedInvestigationalWithdrawnAminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in c...
Categories: P-glycoprotein inhibitorsInternational brands: AMSA P-D